PMID- 18950659
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20220105
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 196
IP  - 2
DP  - 2009 Jan 23
TI  - Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the 
      female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair 
      lordosis.
PG  - 317-22
LID - 10.1016/j.bbr.2008.09.026 [doi]
AB  - Serotonin (5-HT) is known to play a role in the suppression of the lordosis 
      response in males. We have previously shown that there is a sex difference in the 
      density of 5-HT immunoreactive (5-HT-ir) fibers in the ventrolateral division of 
      the adult ventromedial nucleus of the hypothalamus (VMNvl) and that neonatal 
      administration of estradiol (E2) increases 5-HT-ir in the female VMNvl to 
      male-typical levels. Here we demonstrate that postnatal administration of the 
      ERalpha agonist 1,3,5-tris(4-Hydroxyphenyl)-4-propyl-1H-pyrazole (PPT), but not 
      the ERbeta agonist diarylpropionitrile (DPN), also masculinizes 5-HT-ir in the 
      female VMNvl, suggesting a mechanistic role for ERalpha in this process. Sexual 
      receptivity, as ascertained by the lordosis quotient, was unaffected by either 
      PPT or DPN treatment but nearly abolished by estradiol benzoate (EB), a synthetic 
      estrogen with high affinity for both ERalpha and ERbeta. Collectively, these 
      observations show that postnatal estrogens increase the density of 5-HT 
      projections to the VMNvl via an ERalpha dependent mechanism, but that this 
      increased inhibitory input is not sufficient to suppress the lordosis response.
FAU - Patisaul, Heather B
AU  - Patisaul HB
AD  - Department of Biology, North Carolina State University, Raleigh, NC 27695, USA. 
      Heather_patisaul@ncsu.edu
FAU - Adewale, Heather B
AU  - Adewale HB
FAU - Mickens, Jillian A
AU  - Mickens JA
LA  - eng
GR  - R01 ES016001/ES/NIEHS NIH HHS/United States
GR  - R01 ES016001-01/ES/NIEHS NIH HHS/United States
GR  - 1R01ES016001-01/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081004
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (2,3-bis(4-hydroxyphenyl)-propionitrile)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Nitriles)
RN  - 0 (Phenols)
RN  - 0 (Propionates)
RN  - 0 (Pyrazoles)
RN  - 0T83Y6JZPF (4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol)
RN  - 333DO1RDJY (Serotonin)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Estradiol/administration & dosage/pharmacology
MH  - Estrogen Receptor alpha/agonists/*physiology
MH  - Estrogen Receptor beta/agonists
MH  - Female
MH  - Male
MH  - Neural Pathways/*physiology
MH  - Nitriles/pharmacology
MH  - Phenols/pharmacology
MH  - Propionates/pharmacology
MH  - Pyrazoles/pharmacology
MH  - Rats
MH  - Serotonin/*physiology
MH  - Sex Characteristics
MH  - Sexual Behavior, Animal/*physiology
MH  - Ventromedial Hypothalamic Nucleus/*physiology
PMC - PMC2645032
MID - NIHMS84922
EDAT- 2008/10/28 09:00
MHDA- 2009/02/25 09:00
PMCR- 2010/01/23
CRDT- 2008/10/28 09:00
PHST- 2008/07/04 00:00 [received]
PHST- 2008/08/28 00:00 [revised]
PHST- 2008/09/13 00:00 [accepted]
PHST- 2008/10/28 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
PHST- 2008/10/28 09:00 [entrez]
PHST- 2010/01/23 00:00 [pmc-release]
AID - S0166-4328(08)00532-9 [pii]
AID - 10.1016/j.bbr.2008.09.026 [doi]
PST - ppublish
SO  - Behav Brain Res. 2009 Jan 23;196(2):317-22. doi: 10.1016/j.bbr.2008.09.026. Epub 
      2008 Oct 4.