PMID- 18951256
OWN - NLM
STAT- MEDLINE
DCOM- 20081111
LR  - 20220317
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 45
IP  - 8
DP  - 2008 Oct
TI  - The predictive value of IgE as biomarker in asthma.
PG  - 654-63
LID - 10.1080/02770900802126958 [doi]
AB  - BACKGROUND: The evidence for a causal relationship between allergens and asthma 
      depends on epidemiologic findings showing a strong association between specific 
      immunoglobulin E (IgE) antibodies or total IgE and asthma. OBJECTIVE: To clarify 
      the relationship between total serum IgE levels and asthma. STUDY DESIGN: A 
      cross-sectional study. PATIENTS AND METHODS: A total of 562 asthmatic patients 
      were included in the study, and their age range was from 17 to 52 years. The 
      subjects included in the study were outpatients from the Asthma and Allergy 
      Centre or Samara General Hospital outpatients Clinic. The diagnosis of asthma was 
      performed by a specialist physician and was established according to the National 
      Heart Blood and Lung Institute/World Health Organization (NHLBI/WHO) workshop on 
      the Global Strategy for Asthma. RESULTS: This study indicated that mean serum IgE 
      level was 554 +/- 447 IU/mL in asthmatic patients, while that of the control 
      population was 69 +/- 33 IU/mL. There was no overlap in the values of 95% 
      confidence interval (CI) of higher control limit and lower asthmatic limit 
      values. Addition of two standard deviations to the mean IgE value of the control 
      group (134 IU/mL) does not overlap with the lower 95% CI of the asthmatic group. 
      However, serum IgE was within normal values in 5.9% of asthmatic patients in our 
      study population. There was an inverse correlation between serum IgE levels and 
      forced expiratory volume in 1 second (FEV(1)) predicted percent for patients with 
      asthma (r = -0.73, p < 0.0001). The predictive value of serum IgE in asthma was 
      determined using Receiver Operating Characteristics (ROC) curve method. From the 
      ROC curve, it can be seen that it is possible to get both high sensitivity and 
      high specificity if the right cut-off value was chosen. In fact, a cut-off of 200 
      IU/mL would indicate sensitivity of 93% and specificity of 91% in this group of 
      patients and control subjects. Following immunotherapy there was 36% reduction in 
      total serum IgE level. The value of IgE was significantly reduced (p < 0.001) 
      from 956 +/- 378 IU/mL at baseline to 613 +/- 194 IU/mL after treatment. 
      CONCLUSION: Serum IgE level was predictive in asthma, and it may be used to 
      differentiate between asthmatic and non-asthmatic individuals in conjunction with 
      other biomarkers. Specific immunotherapy reduced serum total IgE level in 36% of 
      patients with asthma.
FAU - Ahmad Al Obaidi, Amina Hamed
AU  - Ahmad Al Obaidi AH
AD  - Department of Biochemistry, College of Medicine, Tikrit University, Tikrit, Iraq. 
      aminahamed2006@yahoo.com
FAU - Mohamed Al Samarai, Abdul Ghani
AU  - Mohamed Al Samarai AG
FAU - Yahya Al Samarai, Abdul Kareem
AU  - Yahya Al Samarai AK
FAU - Al Janabi, Jasim Mohamad
AU  - Al Janabi JM
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/diagnosis/*immunology/therapy
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunotherapy
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Respiratory Function Tests
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
EDAT- 2008/10/28 09:00
MHDA- 2008/11/13 09:00
CRDT- 2008/10/28 09:00
PHST- 2008/10/28 09:00 [pubmed]
PHST- 2008/11/13 09:00 [medline]
PHST- 2008/10/28 09:00 [entrez]
AID - 904808935 [pii]
AID - 10.1080/02770900802126958 [doi]
PST - ppublish
SO  - J Asthma. 2008 Oct;45(8):654-63. doi: 10.1080/02770900802126958.