PMID- 18952090
OWN - NLM
STAT- MEDLINE
DCOM- 20090331
LR  - 20181113
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 55
IP  - 1
DP  - 2009 Jan
TI  - Progesterone reduces the effect of the serotonin 1B/1D receptor antagonist, GR 
      127935, on lordosis behavior.
PG  - 169-74
LID - 10.1016/j.yhbeh.2008.09.011 [doi]
AB  - Ovariectomized rats were hormonally primed with 10 microg estradiol benzoate or 
      with estradiol benzoate plus 500 microg progesterone. Rats received a bilateral 
      infusion with 200 ng of the 5-HT(1B/1D) receptor antagonist, 
      N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1-1'-biphenyl-4-carboxamide 
      hydrochloride (GR 127935), into the ventromedial nucleus of the hypothalamus 
      (VMN), followed by a 5 min restraint or home cage experience. In estrogen-primed 
      females that had experienced minimal handling between ovariectomy and use in the 
      experiment, infusion with the water vehicle transiently inhibited lordosis 
      behavior, and the 5-HT(1B/1D) receptor antagonist amplified this inhibition. 
      There were no effects in rats hormonally primed with estrogen and progesterone. 
      Handling for two days before the experiment reduced the effects of the infusions 
      in estrogen-primed rats. However, when a 5 min restraint experience followed 
      infusion with GR 127935, there was a significant decline in lordosis behavior 
      that persisted for 10 to 15 min after the experience. Regardless of the prior 
      experience or type of infusion, the addition of progesterone to the hormonal 
      priming completely prevented the lordosis inhibition. These findings are 
      consistent with prior evidence that progesterone protects against the inhibitory 
      effects of a 5 min restraint experience on lordosis behavior. Moreover, these are 
      the first experiments to demonstrate an inhibitory effect of a selective 
      5-HT(1B/1D) receptor antagonist in the VMN on lordosis behavior of estrogen 
      primed, but not estrogen and progesterone primed, ovariectomized rats.
FAU - Uphouse, Lynda
AU  - Uphouse L
AD  - Department of Biology, Texas Woman's University, Denton, TX 76204, USA. 
      Luphouse@mail.twu.edu
FAU - Hiegel, Cindy
AU  - Hiegel C
FAU - Guptarak, Jutatip
AU  - Guptarak J
FAU - Maswood, Navin
AU  - Maswood N
LA  - eng
GR  - R25 GM055380/GM/NIGMS NIH HHS/United States
GR  - R01 HD028419/HD/NICHD NIH HHS/United States
GR  - R25 GM055380-12/GM/NIGMS NIH HHS/United States
GR  - GM 55380/GM/NIGMS NIH HHS/United States
GR  - R01 HD028419-13A2/HD/NICHD NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081008
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Estrogens)
RN  - 0 (Oxadiazoles)
RN  - 0 (Piperazines)
RN  - 0 (Serotonin 5-HT1 Receptor Antagonists)
RN  - 0 (Serotonin Antagonists)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 2LLH6CEB40 (GR 127935)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Catheterization
MH  - Estradiol/analogs & derivatives/pharmacology
MH  - Estrogens/pharmacology
MH  - Female
MH  - Ovariectomy
MH  - Oxadiazoles/*pharmacology
MH  - Piperazines/*pharmacology
MH  - Posture/*physiology
MH  - Progesterone/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Restraint, Physical
MH  - Serotonin 5-HT1 Receptor Antagonists
MH  - Serotonin Antagonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Ventromedial Hypothalamic Nucleus/drug effects
PMC - PMC2665997
MID - NIHMS93180
EDAT- 2008/10/28 09:00
MHDA- 2009/04/01 09:00
PMCR- 2010/01/01
CRDT- 2008/10/28 09:00
PHST- 2008/07/03 00:00 [received]
PHST- 2008/09/25 00:00 [revised]
PHST- 2008/09/26 00:00 [accepted]
PHST- 2008/10/28 09:00 [pubmed]
PHST- 2009/04/01 09:00 [medline]
PHST- 2008/10/28 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - S0018-506X(08)00273-0 [pii]
AID - 10.1016/j.yhbeh.2008.09.011 [doi]
PST - ppublish
SO  - Horm Behav. 2009 Jan;55(1):169-74. doi: 10.1016/j.yhbeh.2008.09.011. Epub 2008 
      Oct 8.