PMID- 18952501
OWN - NLM
STAT- MEDLINE
DCOM- 20090619
LR  - 20181113
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 29
IP  - 12
DP  - 2008 Dec
TI  - Targeting minor histocompatibility antigens in graft versus tumor or graft versus 
      leukemia responses.
PG  - 624-32
LID - 10.1016/j.it.2008.09.004 [doi]
AB  - Allogeneic hematopoietic cell transplantation (alloHCT) represents the only 
      curative therapy for several hematologic malignancies, and shows promise as a 
      nascent treatment modality for select solid tumors. Although the original goal of 
      alloHCT was hematopoietic reconstitution after sub-lethal chemoradiotherapy, 
      recognition of a profound donor lymphocyte-mediated graft-versus-leukemia (GVL) 
      or graft-versus-tumor (GVT) effect has shifted the paradigm from pre-transplant 
      cytoreduction to tumor control via donor lymphocytes. In human leukocyte antigen 
      (HLA)-compatible alloHCT, GVL and GVT reactions are induced primarily by donor 
      T-cell recognition of minor histocompatibility antigens (mHAgs). Here we review 
      the literature regarding mHAg-specific T cells in GVL and GVT reactions, and 
      discuss the prospects of exploiting mHAgs as immunotherapeutic targets.
FAU - Feng, Xin
AU  - Feng X
AD  - Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA 
      15213, USA.
FAU - Hui, Kwok Min
AU  - Hui KM
FAU - Younes, Hashem M
AU  - Younes HM
FAU - Brickner, Anthony G
AU  - Brickner AG
LA  - eng
GR  - R01 CA118880/CA/NCI NIH HHS/United States
GR  - R01 CA118880-01A1/CA/NCI NIH HHS/United States
GR  - R01 CA118880-02/CA/NCI NIH HHS/United States
GR  - CA118880/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20081025
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Epitopes)
RN  - 0 (Minor Histocompatibility Antigens)
SB  - IM
MH  - Animals
MH  - Epitopes/immunology
MH  - Graft vs Leukemia Effect/*immunology
MH  - Graft vs Tumor Effect/*immunology
MH  - Humans
MH  - Immunotherapy
MH  - Minor Histocompatibility Antigens/*immunology
MH  - Neoplasms/*immunology/*therapy
PMC - PMC2593397
MID - NIHMS79947
EDAT- 2008/10/28 09:00
MHDA- 2009/06/20 09:00
PMCR- 2009/12/01
CRDT- 2008/10/28 09:00
PHST- 2008/05/09 00:00 [received]
PHST- 2008/08/24 00:00 [revised]
PHST- 2008/09/01 00:00 [accepted]
PHST- 2008/10/28 09:00 [pubmed]
PHST- 2009/06/20 09:00 [medline]
PHST- 2008/10/28 09:00 [entrez]
PHST- 2009/12/01 00:00 [pmc-release]
AID - S1471-4906(08)00237-8 [pii]
AID - 10.1016/j.it.2008.09.004 [doi]
PST - ppublish
SO  - Trends Immunol. 2008 Dec;29(12):624-32. doi: 10.1016/j.it.2008.09.004. Epub 2008 
      Oct 25.