PMID- 18953861
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20081028
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 43
IP  - 5
DP  - 2008 May
TI  - [Application of spectral karyotyping in diagnosis and prenatal diagnosis of the 
      marker chromosome].
PG  - 321-4
AB  - OBJECTIVE: To determine the value of spectral karyotyping(SKY) in identification 
      of the marker chromosome. METHODS: Selected six cases that could not be 
      identified in clinic were studied, using samples of peripheral blood from four 
      cases, and samples of amonic fluid and fetal cord blood for prenatal diagnosis in 
      two cases were investigated. All cases were analyzed with the routine SKY method, 
      and the results with the SKY View software. The SKY results were identified by 
      using fluorescence in situ hybridization (FISH). And C-banding technique was used 
      to help diagnose the heterochromatin. RESULTS: SKY was successfully performed on 
      all of 6 cases. The origin of all marker chromosomes was identified by SKY. 
      Except case No. 4, the others were confirmed by FISH. It helped determine the 
      pregnancy outcome in two cases of prenatal diagnosis: one case of genetic marker 
      chromosome continued the pregnancy, and another case of de novo marker chromosome 
      was terminated of the pregnancy. CONCLUSION: SKY may be a valuable tool to 
      diagnose the marker chromosome with rapidness,direct-viewing and sensitiveness. 
      It can be used to assess the prognosis and the pregnancy outcome.
FAU - Liao, Can
AU  - Liao C
AD  - Institute of Eugenics and Perinatology, Women and Children's Hospital of 
      Guangzhou, Guangzhou 510180, China. canliao@hotmail.com
FAU - Pan, Min
AU  - Pan M
FAU - Li, Dong-Zhi
AU  - Li DZ
FAU - Yi, Cui-Xing
AU  - Yi CX
FAU - Hu, Shun-Yan
AU  - Hu SY
FAU - Yuan, Si-Min
AU  - Yuan SM
FAU - Wu, Shao-Qing
AU  - Wu SQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (Genetic Markers)
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Disorders/diagnosis/genetics
MH  - Chromosomes, Human/*genetics
MH  - Chromosomes, Human, Pair 15/genetics
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Prenatal Diagnosis/*methods
MH  - Sensitivity and Specificity
MH  - Spectral Karyotyping/*methods
EDAT- 2008/10/29 09:00
MHDA- 2011/08/16 06:00
CRDT- 2008/10/29 09:00
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
PHST- 2008/10/29 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2008 May;43(5):321-4.