PMID- 18955015
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20181113
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 130
IP  - 2
DP  - 2009 Feb
TI  - Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in 
      murine asthma.
PG  - 186-98
LID - 10.1016/j.clim.2008.08.029 [doi]
AB  - Matrix metalloproteinases (MMPs) modulate development, inflammation, and repair 
      in lungs. Tissue inhibitors of MMPs (TIMPs) interact with MMPs, controlling the 
      intensity and nature of the response to injury. Absence of MMP-9, -2, and -8 
      activities is associated with altered lung inflammation during allergic 
      sensitization. To test the hypothesis that the absence of TIMP-1 enhances 
      allergic lung inflammation, airway hyperreactivity (AHR), and lung remodeling in 
      asthma, we studied TIMP-1 null (TIMP-1 KO) mice and their WT controls using an 
      ovalbumin (OVA) asthma model. TIMP-1 KO mice, compared to WT controls, developed 
      an asthma phenotype characterized by AHR, pronounced cellular lung infiltrates, 
      greater reduction in lung compliance, enhanced Th2 cytokine mRNA and protein 
      expression, and altered collagen lung content associated with enhanced MMP-9 
      activity. Our findings support the hypothesis that TIMP-1 plays a protective role 
      by preventing AHR and modulating inflammation, remodeling, and cytokine 
      expression in an animal model of asthma.
FAU - Sands, Mark F
AU  - Sands MF
AD  - VA Western New York Healthcare System, Buffalo, NY 14215, USA. 
      mfsands@buffalo.edu
FAU - Ohtake, Patricia J
AU  - Ohtake PJ
FAU - Mahajan, Supriya D
AU  - Mahajan SD
FAU - Takyar, Shervin S
AU  - Takyar SS
FAU - Aalinkeel, Ravikumar
AU  - Aalinkeel R
FAU - Fang, Yisheng V
AU  - Fang YV
FAU - Blume, Jessica W
AU  - Blume JW
FAU - Mullan, Barbara A
AU  - Mullan BA
FAU - Sykes, Don E
AU  - Sykes DE
FAU - Lachina, Sandra
AU  - Lachina S
FAU - Knight, Paul R
AU  - Knight PR
FAU - Schwartz, Stanley A
AU  - Schwartz SA
LA  - eng
GR  - R01 HL048889/HL/NHLBI NIH HHS/United States
GR  - R01 HL048889-09/HL/NHLBI NIH HHS/United States
GR  - HL 48889/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081026
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Animals
MH  - Asthma/chemically induced/*immunology
MH  - Cytokines/biosynthesis/*immunology
MH  - Disease Models, Animal
MH  - Gene Expression
MH  - Hydroxyproline/immunology/metabolism
MH  - Immunoglobulin E/blood
MH  - Lung/immunology/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology
MH  - Pneumonia/*immunology/pathology
MH  - RNA, Messenger/immunology/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/genetics/*immunology/metabolism
PMC - PMC2676334
MID - NIHMS89572
EDAT- 2008/10/29 09:00
MHDA- 2009/01/28 09:00
PMCR- 2010/02/01
CRDT- 2008/10/29 09:00
PHST- 2008/07/07 00:00 [received]
PHST- 2008/08/08 00:00 [revised]
PHST- 2008/08/30 00:00 [accepted]
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/10/29 09:00 [entrez]
PHST- 2010/02/01 00:00 [pmc-release]
AID - S1521-6616(08)00818-8 [pii]
AID - 10.1016/j.clim.2008.08.029 [doi]
PST - ppublish
SO  - Clin Immunol. 2009 Feb;130(2):186-98. doi: 10.1016/j.clim.2008.08.029. Epub 2008 
      Oct 26.