PMID- 18955350
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20240323
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Print)
IS  - 1741-427X (Linking)
VI  - 2011
DP  - 2011
TI  - Antidiabetic Indian plants: a good source of potent amylase inhibitors.
PG  - 810207
LID - 10.1093/ecam/nen040 [doi]
LID - 810207
AB  - Diabetes is known as a multifactorial disease. The treatment of diabetes (Type 
      II) is complicated due to the inherent patho-physiological factors related to 
      this disease. One of the complications of diabetes is post-prandial hyperglycemia 
      (PPHG). Glucosidase inhibitors, particularly alpha-amylase inhibitors are a class of 
      compounds that helps in managing PPHG. Six ethno-botanically known plants having 
      antidiabetic property namely, Azadirachta indica Adr. Juss.; Murraya koenigii 
      (L.) Sprengel; Ocimum tenuflorum (L.) (syn: Sanctum); Syzygium cumini (L.) Skeels 
      (syn: Eugenia jambolana); Linum usitatissimum (L.) and Bougainvillea spectabilis 
      were tested for their ability to inhibit glucosidase activity. The chloroform, 
      methanol and aqueous extracts were prepared sequentially from either leaves or 
      seeds of these plants. It was observed that the chloroform extract of O. 
      tenuflorum; B. spectabilis; M. koenigii and S. cumini have significant alpha-amylase 
      inhibitory property. Plants extracts were further tested against murine 
      pancreatic, liver and small intestinal crude enzyme preparations for glucosidase 
      inhibitory activity. The three extracts of O. tenuflorum and chloroform extract 
      of M. koenigi showed good inhibition of murine pancreatic and intestinal 
      glucosidases as compared with acarbose, a known glucosidase inhibitor.
FAU - Bhat, Menakshi
AU  - Bhat M
AD  - Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411 007, 
      India.
FAU - Zinjarde, Smita S
AU  - Zinjarde SS
FAU - Bhargava, Shobha Y
AU  - Bhargava SY
FAU - Kumar, Ameeta Ravi
AU  - Kumar AR
FAU - Joshi, Bimba N
AU  - Joshi BN
LA  - eng
PT  - Journal Article
DEP - 20110502
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3137644
EDAT- 2008/10/29 09:00
MHDA- 2008/10/29 09:01
PMCR- 2011/05/02
CRDT- 2008/10/29 09:00
PHST- 2007/04/21 00:00 [received]
PHST- 2008/04/11 00:00 [accepted]
PHST- 2008/10/29 09:00 [entrez]
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2008/10/29 09:01 [medline]
PHST- 2011/05/02 00:00 [pmc-release]
AID - nen040 [pii]
AID - 10.1093/ecam/nen040 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2011;2011:810207. doi: 10.1093/ecam/nen040. 
      Epub 2011 May 2.