PMID- 18955786
OWN - NLM
STAT- MEDLINE
DCOM- 20081218
LR  - 20181113
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 23
IP  - 5
DP  - 2008 Oct
TI  - Outcomes of pregnancy in women with congenital heart disease: a single center 
      experience in Korea.
PG  - 808-13
LID - 10.3346/jkms.2008.23.5.808 [doi]
AB  - Pregnancy outcomes in patients with congenital heart disease have not been fully 
      assessed in Korea. Forty-nine pregnancies that occurred in 34 women with 
      congenital heart disease who registered at our hospital between September 1995 
      and April 2006 were reviewed. Spontaneous abortions occurred in two pregnancies 
      at 6+1 and 7 weeks, and another two underwent elective pregnancy termination. One 
      maternal death in puerperium occurred in a woman with Eisenmenger syndrome. 
      Maternal cardiac complications were noted in 18.4%, pulmonary edema in 16.3%, 
      symptomatic arrhythmia in 6.1%, deterioration of New York Heart Association 
      (NYHA) functional class by >or=2 in 2.0%, and cardiac death in 2.0%. Independent 
      predictors of adverse maternal cardiac events were an NYHA functional class of 
      >or=3 (odds ratio [OR], 20.3), right ventricular dilation (OR, 21.2), and 
      pulmonary hypertension (OR, 21.8). Neonatal complications occurred in 22.4% of 
      pregnancies and included preterm delivery (16.3%), small for gestational age 
      (12.2%), and neonatal death (2.0%). Independent predictors of adverse neonatal 
      events were pulmonary hypertension (OR, 6.8) and NYHA functional class>or=3 (OR, 
      23.0). Pregnancy in women with congenital heart disease was found to be 
      significantly associated with maternal cardiac and neonatal complications. 
      Pre-pregnancy counseling and multidisciplinary care involving cardiologists and 
      obstetricians are recommended for women with congenital heart disease 
      contemplating pregnancy.
FAU - Song, Young Bin
AU  - Song YB
AD  - Department of Medicine, Sungkyunkwan University School of Medicine, Grown-Up 
      Congenital Heart Disease Clinic, Cardiac and Vascular Center, Samsung Medical 
      Center, Seoul, Korea.
FAU - Park, Seung Woo
AU  - Park SW
FAU - Kim, Jun Hyung
AU  - Kim JH
FAU - Shin, Dae-Hee
AU  - Shin DH
FAU - Cho, Sung Won
AU  - Cho SW
FAU - Choi, Jin-Oh
AU  - Choi JO
FAU - Lee, Sang-Chol
AU  - Lee SC
FAU - Moon, Ju Ryoung
AU  - Moon JR
FAU - Huh, June
AU  - Huh J
FAU - Kang, I-Seok
AU  - Kang IS
FAU - Lee, Heung Jae
AU  - Lee HJ
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Abortion, Spontaneous
MH  - Adult
MH  - Female
MH  - Heart Defects, Congenital/complications/*physiopathology
MH  - Humans
MH  - Korea
MH  - Multivariate Analysis
MH  - Obstetrics/methods
MH  - Odds Ratio
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/physiopathology
MH  - Pregnancy Outcome
PMC - PMC2579998
EDAT- 2008/10/29 09:00
MHDA- 2008/12/19 09:00
PMCR- 2008/10/01
CRDT- 2008/10/29 09:00
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2008/12/19 09:00 [medline]
PHST- 2008/10/29 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - 200810808 [pii]
AID - 10.3346/jkms.2008.23.5.808 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2008 Oct;23(5):808-13. doi: 10.3346/jkms.2008.23.5.808.