PMID- 18955791
OWN - NLM
STAT- MEDLINE
DCOM- 20081218
LR  - 20181113
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 23
IP  - 5
DP  - 2008 Oct
TI  - Human leukocyte antigen class II association with spontaneous recovery from 
      hepatitis B virus infection in Koreans: analysis at the haplotype level.
PG  - 838-44
LID - 10.3346/jkms.2008.23.5.838 [doi]
AB  - It has been speculated that human leukocyte antigen (HLA) alleles are associated 
      with the outcome of hepatitis B virus (HBV) infection although the data obtained 
      from various populations have shown some inconsistencies. A total of 464 
      HBVinfected Korean individuals (80 spontaneously recovered [SR] and 384 
      chronically infected [CI]) were selected to investigate the association of HLA 
      class II alleles with the viral clearance and persistence. Our results showed 
      that: 1) multiple HLA class II alleles and haplotypes were associated with viral 
      clearance (DRB1*1302, DRB1*1502, DQB1*0302, DQB1*0609, and related-haplotypes) 
      and persistence (DRB1*0701, DQB1*0301, and related-haplotypes); 2) DRB1*1302 and 
      DQB1* 0609 were more strongly associated with viral clearance. And the 
      association of DQB1*0609 (pc=0.0084; OR, 7.24) with vial clearance was much 
      stronger than previously recognized, DRB1*1302 (pc=0.0038; OR, 4.34); and 3) 
      linkage to a specific DPB1 allele in a haplotype strengthened the association 
      with viral clearance, although DPB1 itself was not associated with the outcome. 
      These results indicate the existence of multiple factors controlling viral 
      clearance in the HLA class II gene region. Further extended investigation on the 
      genetic factors related to the outcome of HBV infection will provide valuable 
      insights into the understanding of the mechanisms involved.
FAU - Cho, Sung Won
AU  - Cho SW
AD  - Department of Gastroenterology, Genomic Research Center for Gastroenterology, 
      Ajou University School of Medicine, Suwon, Korea.
FAU - Cheong, Jae Youn
AU  - Cheong JY
FAU - Ju, Young Su
AU  - Ju YS
FAU - Oh, Do Hoon
AU  - Oh DH
FAU - Suh, Young Ju
AU  - Suh YJ
FAU - Lee, Kyung Wha
AU  - Lee KW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - *Genes, MHC Class II
MH  - HLA Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - *Haplotypes
MH  - Hepatitis B/*immunology/*virology
MH  - Hepatitis B virus/genetics
MH  - Humans
MH  - Immunophenotyping
MH  - Korea
MH  - Models, Genetic
MH  - Remission Induction
MH  - Treatment Outcome
PMC - PMC2579996
EDAT- 2008/10/29 09:00
MHDA- 2008/12/19 09:00
PMCR- 2008/10/01
CRDT- 2008/10/29 09:00
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2008/12/19 09:00 [medline]
PHST- 2008/10/29 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - 200810838 [pii]
AID - 10.3346/jkms.2008.23.5.838 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2008 Oct;23(5):838-44. doi: 10.3346/jkms.2008.23.5.838.