PMID- 18955824
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20081028
IS  - 1017-7825 (Print)
IS  - 1017-7825 (Linking)
VI  - 18
IP  - 10
DP  - 2008 Oct
TI  - Characterization of interaction between porcine reproductive and respiratory 
      syndrome virus and porcine dendritic cells.
PG  - 1709-16
AB  - The porcine reproductive and respiratory syndrome Virus (PRRSV) is an infectious 
      disease that causes abortions and respiratory disorders in swine. In this study, 
      the interaction between PRRSV and porcine dendritic cells generated from CD14(+) 
      monocytes in the presence of GM-CSF and IL-4 was examined. As a result, it was 
      shown that immature and mature dendritic cells can be productively infected with 
      PRRSV. When the expression of surface MHC molecules on infected dendritic cells 
      was determined, MHC classes I and II were found to be downregulated when compared 
      with uninfected dendritic cells. With the exception of the IL-4 and IFN-gamma 
      cytokines, the induction of the IL-10, IL-12, and TNF-alpha cytokines all 
      increased in dendritic cells infected with PRRSV. A mixed lymphocyte reaction 
      showed that peripheral blood mononuclear cells cocultured with PRRSVinfected 
      dendritic cells were less stimulated than peripheral blood mononuclear cells 
      cocultured with dendritic cells treated with PBS, LPS, or UV-inactivated PRRSV. 
      Therefore, these results suggest that PRRSV would appear to modulate the immune 
      stimulatory function of porcine dendritic cells.
FAU - Park, Jie Yeun
AU  - Park JY
AD  - Division of Preventive Medicine, College of Veterinary Medicine, Chungnam 
      National University, Daejeon 305-764, Korea.
FAU - Kim, Hyun Soo
AU  - Kim HS
FAU - Seo, Sang Heui
AU  - Seo SH
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Microbiol Biotechnol
JT  - Journal of microbiology and biotechnology
JID - 9431852
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/*virology
MH  - Interferon-gamma/immunology
MH  - Interleukin-4/immunology
MH  - Major Histocompatibility Complex
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
EDAT- 2008/10/29 09:00
MHDA- 2009/06/09 09:00
CRDT- 2008/10/29 09:00
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
PHST- 2008/10/29 09:00 [entrez]
AID - 8109 [pii]
PST - ppublish
SO  - J Microbiol Biotechnol. 2008 Oct;18(10):1709-16.