PMID- 18958757
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20091120
IS  - 1607-842X (Electronic)
IS  - 0891-6934 (Linking)
VI  - 41
IP  - 8
DP  - 2008 Dec
TI  - Stem cell transplantation for autoimmune diseases: what can we learn from 
      experimental models?
PG  - 563-9
LID - 10.1080/08916930802197909 [doi]
AB  - Using animal models for autoimmune diseases, we have previously shown that 
      allogeneic bone marrow transplantation (allo BMT) can be used to treat autoimmune 
      diseases. Using cynomolgus monkeys, we have recently developed new BMT methods 
      for the treatment of autoimmune diseases. The methods include the perfusion 
      method (PM) for the collection of bone marrow cells (BMCs), and intra-bone marrow 
      (IBM)-BMT for the direct injection of collected whole BMCs into the bone marrow 
      cavity. The PM, in comparison with the conventional aspiration method, can 
      minimize the contamination of BMCs with T cells from the peripheral blood. 
      Therefore, without removing T cells, no graft-versus-host disease (GvHD) develops 
      in the case of the PM. Since BMCs collected by the PM contain not only 
      hemopoietic stem cells (HSCs) but also mesenchymal stem cells (MSCs), the 
      injection of both cells directly into the bone marrow cavity (IBM-BMT) 
      facilitates the engraftment of donor hemopoietic cells. In organ allografts with 
      IBM-BMT, no graft failure occurs even if the radiation dose is reduced. In 
      addition, IBM-BMT is applicable to regeneration therapy and various 
      age-associated diseases such as osteoporosis, since it can efficiently recruit 
      donor-derived normal MSCs. We have also found that IBM-BMT in conjunction with 
      donor lymphocyte infusion can prevent GvHD, but suppress tumor growth. We believe 
      that this strategy heralds a revolution in the field of transplantation (BMT and 
      organ allografts) and regeneration therapy.
FAU - Ikehara, Susumu
AU  - Ikehara S
AD  - First Department of Pathology, Transplantation Center, Regeneration Research 
      Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical 
      University, Moriguchi City, Osaka, Japan. ikehara@takii.kmu.ac.jp
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*therapy
MH  - Bone Marrow Transplantation/*methods
MH  - *Disease Models, Animal
MH  - Graft vs Host Disease/prevention & control
MH  - Humans
MH  - Regenerative Medicine/methods
RF  - 76
EDAT- 2008/10/30 09:00
MHDA- 2010/03/05 06:00
CRDT- 2008/10/30 09:00
PHST- 2008/10/30 09:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
PHST- 2008/10/30 09:00 [entrez]
AID - 904878397 [pii]
AID - 10.1080/08916930802197909 [doi]
PST - ppublish
SO  - Autoimmunity. 2008 Dec;41(8):563-9. doi: 10.1080/08916930802197909.