PMID- 18958766
OWN - NLM
STAT- MEDLINE
DCOM- 20090128
LR  - 20220321
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 24
IP  - 9
DP  - 2008 Sep
TI  - Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic 
      ovary syndrome.
PG  - 486-90
LID - 10.1080/09513590802196379 [doi]
AB  - Polycystic ovary syndrome (PCOS), the most common reproductive endocrine disorder 
      of premenopausal women, is strongly associated with hyperinsulinemia and type 2 
      diabetes mellitus (T2DM). Given the phenotypic overlap between PCOS and T2DM, our 
      objective was to investigate whether the TCF7L2 rs7903146(C/T) and the KCNJ11 
      E23K variants are involved in susceptibility to PCOS and related traits in a 
      Greek population. A total of 183 PCOS patients and 148 healthy controls 
      participated. All participants were Greeks. Blood was taken before hormonal 
      therapy. PCOS patients and healthy controls were genotyped for the TCF7L2 and 
      KCNJ11 variants. The T allele of the TCF7L2 rs7903146 variant was found to be 
      marginally over-represented in Greek patients with PCOS. There was no association 
      between KCNJ11 E23K polymorphism and PCOS in the present study. In addition, 
      there were no associations observed between hormone levels and insulin resistance 
      in PCOS carriers of TCF7L2 rs7903146 and KCNJ11 E23K variants. These data provide 
      evidence that the rs7903146 variant of the TCF7L2 gene might influence PCOS 
      predisposition, while no association is observed between the E23K variant of 
      KCNJ11 and susceptibility to PCOS and related traits.
FAU - Christopoulos, Panagiotis
AU  - Christopoulos P
AD  - Second Department of Obstetrics and Gynecology, School of Medicine, University of 
      Athens, Athens, Greece. dr_christopoulos@yahoo.gr
FAU - Mastorakos, George
AU  - Mastorakos G
FAU - Gazouli, Maria
AU  - Gazouli M
FAU - Panidis, Dimitrios
AU  - Panidis D
FAU - Deligeoroglou, Efthimios
AU  - Deligeoroglou E
FAU - Katsikis, Ilias
AU  - Katsikis I
FAU - Papadias, Konstantinos
AU  - Papadias K
FAU - Diamandi-Kandarakis, Evanthia
AU  - Diamandi-Kandarakis E
FAU - Creatsas, George
AU  - Creatsas G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Kir6.2 channel)
RN  - 0 (Mutant Proteins)
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 0 (TCF Transcription Factors)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Greece
MH  - Humans
MH  - Mutant Proteins/genetics
MH  - Polycystic Ovary Syndrome/*genetics
MH  - *Polymorphism, Genetic
MH  - Potassium Channels, Inwardly Rectifying/*genetics
MH  - TCF Transcription Factors/*genetics
MH  - Transcription Factor 7-Like 2 Protein
MH  - Young Adult
EDAT- 2008/10/30 09:00
MHDA- 2009/01/29 09:00
CRDT- 2008/10/30 09:00
PHST- 2008/10/30 09:00 [pubmed]
PHST- 2009/01/29 09:00 [medline]
PHST- 2008/10/30 09:00 [entrez]
AID - 904869966 [pii]
AID - 10.1080/09513590802196379 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2008 Sep;24(9):486-90. doi: 10.1080/09513590802196379.