PMID- 18959015
OWN - NLM
STAT- MEDLINE
DCOM- 20090107
LR  - 20081030
IS  - 1405-9940 (Print)
IS  - 1665-1731 (Linking)
VI  - 78
IP  - 3
DP  - 2008 Jul-Sep
TI  - [Initiation mode of ventricular tachyarrhythmias in chronic Chagas' 
      cardiomyopathy].
PG  - 279-84
AB  - AIM: The purpose of this study was to investigate the modes of initiation of 
      malignant ventricular tachyarrhythmias in patients with Chagas' cardiomyopathy 
      (ChC) with an implantable cardioverter-defibrillator (ICD) through the analysis 
      of stored intracardiac electrograms. Specifically, we analyzed the incidence of 
      ventricular arrhythmias preceded by the short-long-short-pattern (sls). METHODS: 
      We analyzed 179 spontaneous malignant ventricular tachyarrhythmias episodes in 15 
      patients with Chagas' cardiomyopathy with an ICD. The mean cycle length in normal 
      sinus rhythm before initiation of the malignant ventricular tachyarrhythmias, the 
      ventricular tachycardia (VT) cycle length, the prematurity ratio and the number 
      of ventricular premature contractions (VPCs) (single, pairs or multiple) that 
      triggered malignant ventricular tachyarrhythmias were compared between the two 
      different initiation modes. RESULTS: Mean age: 60.4 +/- 5.7 -years-old, mean EF, 
      33.2 +/- 8.5%, 9 men and 6 women. A sls-pattern was found in 43.5% of the 
      malignant ventricular tachyarrhythmias. Baseline cycle length (795 +/- 16 vs 788 
      +/- 14 ms), VT cycle length (320 +/- 7.7 ms vs 329 +/- 5.7 ms) and prematurity 
      ratio (0.57 +/- 11 vs 0.60 +/- 12) were similar between sls and 
      non-sls-sequences. Multiple VPCs as a trigger of malignant ventricular 
      tachyarrhythmias was significantly less often in sls-events than in non-sls 
      events (14% vs 40%; P < 0.0001). CONCLUSIONS: In this select population of 
      patients with ChC, we observed a high prevalence of sls-pattern just before 
      initiation of malignant ventricular tachyarrhythmias. Multiple VPCs were often 
      associated with a non-sls trigger mode.
FAU - Rabinovich, Rafael F
AU  - Rabinovich RF
AD  - Departamento Cardiovascular, Sanatorio Trinidad Mitre, Buenos Aires, Argentina.
FAU - Muratore, Claudio A
AU  - Muratore CA
FAU - Baranchuk, Adrian
AU  - Baranchuk A
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Modo de inicio de las taquiarritmias ventriculares en la cardiopatia chagasica 
      cronica.
PL  - Mexico
TA  - Arch Cardiol Mex
JT  - Archivos de cardiologia de Mexico
JID - 101126728
SB  - IM
MH  - Chagas Cardiomyopathy/physiopathology/*therapy
MH  - *Defibrillators, Implantable
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tachycardia, Ventricular/physiopathology/*therapy
EDAT- 2008/10/31 09:00
MHDA- 2009/01/08 09:00
CRDT- 2008/10/31 09:00
PHST- 2008/10/31 09:00 [pubmed]
PHST- 2009/01/08 09:00 [medline]
PHST- 2008/10/31 09:00 [entrez]
PST - ppublish
SO  - Arch Cardiol Mex. 2008 Jul-Sep;78(3):279-84.