PMID- 18969168
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20081030
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 61
IP  - 2
DP  - 2003 Oct 17
TI  - Study of interactions between DNA-ethidium bromide (EB) and DNA-acridine orange 
      (AO), in solution, using hanging mercury drop electrode (HMDE).
PG  - 103-12
LID - 10.1016/S0039-9140(03)00238-8 [doi]
AB  - The interaction of ethidium bromide (EB) and acridine orange (AO) with double 
      stranded (ds), thermally denatured (ss) and supercoiled (sc) DNA, in solution, 
      was studied by alternating current voltammetry (AC voltammetry) at the hanging 
      mercury drop electrode (HMDE) in 0.3 M NaCl+50 mM sodium phosphate buffer (pH 
      8.5). Their interaction with DNA is shown to be time dependent and completely 
      different. The changes at peak 2 (peak at -1.20 V) of dsDNA form and the 
      appearance of peak 3 (peak at -1.42 V) in scDNA form are presented as criteria 
      declaring the different mechanism of interaction of EB and AO with DNA. 
      Additionally, the appearance of a new peak at around -0.44 V as a result of DNA 
      and AO interaction, differentiates the studied behaviors. The comparison of the 
      electrochemical behaviors of these compounds highlights the differences in the 
      mechanism of interaction.
FAU - Gherghi, I Ch
AU  - Gherghi ICh
AD  - Analytical Chemistry Laboratory, Department of Chemical Engineering, Aristotle 
      University of Thessaloniki, 54124 Thessaloniki, Greece.
FAU - Girousi, S T
AU  - Girousi ST
FAU - Voulgaropoulos, A N
AU  - Voulgaropoulos AN
FAU - Tzimou-Tsitouridou, R
AU  - Tzimou-Tsitouridou R
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
EDAT- 2008/10/31 09:00
MHDA- 2008/10/31 09:01
CRDT- 2008/10/31 09:00
PHST- 2002/12/18 00:00 [received]
PHST- 2003/03/17 00:00 [revised]
PHST- 2003/03/18 00:00 [accepted]
PHST- 2008/10/31 09:00 [pubmed]
PHST- 2008/10/31 09:01 [medline]
PHST- 2008/10/31 09:00 [entrez]
AID - S0039-9140(03)00238-8 [pii]
AID - 10.1016/S0039-9140(03)00238-8 [doi]
PST - ppublish
SO  - Talanta. 2003 Oct 17;61(2):103-12. doi: 10.1016/S0039-9140(03)00238-8.