PMID- 18969364
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20081030
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 62
IP  - 4
DP  - 2004 Mar 10
TI  - Direct and simultaneous determination of arsenic, manganese, cobalt and nickel in 
      urine with a multielement graphite furnace atomic absorption spectrometer.
PG  - 791-9
LID - 10.1016/j.talanta.2003.09.031 [doi]
AB  - A simple method was developed for the direct and simultaneous determination of 
      arsenic (As), manganese (Mn), cobalt (Co), and nickel (Ni) in urine by a 
      multi-element graphite furnace atomic absorption spectrometer (Perkin-Elmer SIMAA 
      6000) equipped with the transversely heated graphite atomizer and longitudinal 
      Zeeman-effect background correction. Pd was used as the chemical modifier along 
      with either the internal furnace gas or a internal furnace gas containing 
      hydrogen and a double stage pyrolysis process. A standard reference material 
      (SRM) of Seronormtrade mark Trace Elements in urine was used to confirm the 
      accuracy of the method. The optimum conditions for the analysis of urine samples 
      are pyrolysis at 1350 degrees C (using 5% H(2) v/v in Ar as the inter furnace gas 
      during the first pyrolysis stage and pure Ar during the second pyrolysis stage) 
      and atomization at 2100 degrees C. The use of Ar and matrix-free standards 
      resulted in concentrations for all the analytes within 85% (As) to 110% (Ni) of 
      the certified values. The recovery for As was improved when mixture of 5% H(2) 
      and 95% Ar (v/v) internal furnace gas was applied during the first step of a 
      two-stage pyrolysis at 1350 degrees C, and the found values of the analytes were 
      within 91-110% of the certified value. The recoveries for real urine samples were 
      in the range 88-95% for these four elements. The detection limits were 
      0.78mugl(-1) for As, 0.054mugl(-1) for Mn, 0.22mugl(-1) for Co, and 0.35mugl(-1) 
      for Ni. The upper limits of the linear calibration curve are 60mugl(-1) (As); 
      12mugl(-1) (Mn); 12mugl(-1) (Co) and 25mugl(-1) (Ni), respectively. The relative 
      standard deviations (R.S.D.s) for the analysis of SRM were 2% or less. The 
      R.S.D.s of a real urine sample are 1.6% (As), 6.3% (Mn), 7.0% (Ni) and 8.0% (Co), 
      respectively.
FAU - Hsiang, Man-Ching
AU  - Hsiang MC
AD  - Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.
FAU - Sung, Yu-Hsiang
AU  - Sung YH
FAU - Huang, Shang-Da
AU  - Huang SD
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
EDAT- 2008/10/31 09:00
MHDA- 2008/10/31 09:01
CRDT- 2008/10/31 09:00
PHST- 2003/07/18 00:00 [received]
PHST- 2003/09/29 00:00 [revised]
PHST- 2003/09/29 00:00 [accepted]
PHST- 2008/10/31 09:00 [pubmed]
PHST- 2008/10/31 09:01 [medline]
PHST- 2008/10/31 09:00 [entrez]
AID - S0039-9140(03)00573-3 [pii]
AID - 10.1016/j.talanta.2003.09.031 [doi]
PST - ppublish
SO  - Talanta. 2004 Mar 10;62(4):791-9. doi: 10.1016/j.talanta.2003.09.031.