PMID- 18972577
OWN - NLM
STAT- MEDLINE
DCOM- 20090410
LR  - 20161124
IS  - 1932-6254 (Print)
IS  - 1932-6254 (Linking)
VI  - 2
IP  - 8
DP  - 2008 Dec
TI  - Use of autologous bone marrow cells concentrate enriched with platelet-rich 
      fibrin on corticocancellous bone allograft for posterolateral multilevel cervical 
      fusion.
PG  - 515-20
LID - 10.1002/term.121 [doi]
AB  - The outcomes of posterolateral multilevel spine fusion in difficult clinical 
      settings, such as in an aged multi-diseased osteoporotic patient, remain 
      unpredictable. The osteoprogenitor cells in bone marrow decrease with ageing 
      without losing their osteogeneic potential. Autologous bone marrow cells (BMCs) 
      from iliac crest aspirate can be concentrated in the operating room and 
      platelet-rich fibrin (PRF) can be obtained from a peripheral blood as a source of 
      autologous osteoprogenitor cells and growth factors, respectively. We present the 
      case of an 88 year-old multi-diseased osteoporotic patient affected by cervical 
      stenosis and subjected to C3--C7 posterior decompression, instrumentation and 
      posterolateral fusion, using an intraoperative 'tissue-engineered' composite made 
      of corticocancellous bone allograft augmented with autologous BMCs concentrate 
      from iliac crest aspirate enriched with PRF from peripheral blood. Lateral 
      dynamic X-rays and CT scan showed consolidation signs at 3 months follow-up, with 
      solid C3--C7 fusion at 6 months follow-up. This paper describes a simple and 
      effective method for potentially improving the fusion rate in aged osteoporotic 
      patients by using corticocancellous bone allograft augmented with autologous BMCs 
      concentrate from the iliac crest, enriched with PRF from peripheral blood, 
      rapidly obtained before the surgical procedure.
CI  - (c) 2008 John Wiley & Sons, Ltd.
FAU - Vadala, Gianluca
AU  - Vadala G
AD  - Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Rome, 
      Italy.
FAU - Di Martino, Alberto
AU  - Di Martino A
FAU - Tirindelli, Maria Cristina
AU  - Tirindelli MC
FAU - Denaro, Luca
AU  - Denaro L
FAU - Denaro, Vincenzo
AU  - Denaro V
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Tissue Eng Regen Med
JT  - Journal of tissue engineering and regenerative medicine
JID - 101308490
RN  - 0 (Antigens, CD)
RN  - 9001-31-4 (Fibrin)
SB  - IM
MH  - Aged, 80 and over
MH  - Antigens, CD
MH  - Blood Platelets/*metabolism
MH  - Bone Marrow Cells/*metabolism
MH  - *Bone Transplantation
MH  - Cervical Vertebrae/diagnostic imaging/*pathology
MH  - Fibrin/*metabolism
MH  - Humans
MH  - Intraoperative Care
MH  - Male
MH  - Radiography
MH  - Spinal Diseases/diagnostic imaging/*therapy
MH  - *Spinal Fusion
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2008/10/31 09:00
MHDA- 2009/04/11 09:00
CRDT- 2008/10/31 09:00
PHST- 2008/10/31 09:00 [pubmed]
PHST- 2009/04/11 09:00 [medline]
PHST- 2008/10/31 09:00 [entrez]
AID - 10.1002/term.121 [doi]
PST - ppublish
SO  - J Tissue Eng Regen Med. 2008 Dec;2(8):515-20. doi: 10.1002/term.121.