PMID- 18973470
OWN - NLM
STAT- MEDLINE
DCOM- 20090220
LR  - 20181201
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 116
IP  - 1
DP  - 2009 Jan
TI  - Statins for heart failure: still caught in no man's land?
PG  - 37-9
LID - 10.1042/CS20080530 [doi]
AB  - Statins are well-known for their ability to lower serum cholesterol levels, but 
      have properties beyond mere cholesterol reduction, including an improvement in 
      endothelial dysfunction, release of endothelial progenitor cells, 
      anti-inflammatory properties and a number of antitumour activities. In the 
      present issue of Clinical Science, Stumpf et al. show that a 4-week treatment 
      course with the lipophilic statin atorvastatin ameliorates left ventricular 
      remodelling and function, reduces serum levels of TNF-alpha (tumour necrosis 
      factor-alpha), IL (interleukin)-6 and MCP-1 (monocyte chemoattractant protein-1), 
      and increases both serum and myocardial levels of IL-10. The authors hypothesize 
      that this shift from a pro- to an anti-inflammatory response might be beneficial 
      in the clinical setting, because patients with low levels of IL-10 may fare worse 
      than those with higher levels. In light of the recent setbacks with rosuvastatin 
      in large-scale clinical trials, this notion requires further investigation, but 
      highlights the need to identify those patients with heart failure who are likely 
      to benefit from statin therapy.
FAU - von Haehling, Stephan
AU  - von Haehling S
AD  - Applied Cachexia Research, Department of Cardiology, Charite Medical School, 
      Campus Virchow-Klinikum, D-13353 Berlin, Germany. stephan.von.haehling@web.de
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Pyrroles)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
CON - Clin Sci (Lond). 2009 Jan;116(1):45-52. PMID: 18459941
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Atorvastatin
MH  - Evidence-Based Medicine
MH  - Heart Failure/*drug therapy
MH  - Heptanoic Acids/therapeutic use
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Inflammation Mediators/blood
MH  - Pyrroles/therapeutic use
RF  - 30
EDAT- 2008/11/01 09:00
MHDA- 2009/02/21 09:00
CRDT- 2008/11/01 09:00
PHST- 2008/11/01 09:00 [pubmed]
PHST- 2009/02/21 09:00 [medline]
PHST- 2008/11/01 09:00 [entrez]
AID - CS20080530 [pii]
AID - 10.1042/CS20080530 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2009 Jan;116(1):37-9. doi: 10.1042/CS20080530.