PMID- 18974575
OWN - NLM
STAT- MEDLINE
DCOM- 20090210
LR  - 20221207
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 19
IP  - 6
DP  - 2008 Nov
TI  - Correlation of urinary monocyte chemo-attractant protein-1 with other parameters 
      of renal injury in type-II diabetes mellitus.
PG  - 911-7
AB  - Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the 
      western world. Increased number of interstitial macrophages has been observed in 
      biopsies from patients with DN. Monocyte chemo-attractant protein-1 (MCP-1) is 
      the strongest known chemo-tactic factor for monocytes and is upregulated in DN. 
      We examined urinary levels of MCP-1 in patients with type-2 diabetes mellitus 
      (DM) to assess its possible correlation with other para-meters of renal injury. 
      The urinary MCP-1 level was assessed in 75 patients with type-2 DM (25 patients 
      each with no microalbuminuria, with macroalbuminuria and, with renal impairment) 
      and compared them with matched healthy control subjects. The HbA1c and estimated 
      glomerular filtration rate (eGFR) derived from the abbreviated Modification of 
      Diet in Renal Disease (MDRD) equation were examined in the study groups in 
      relation to the urinary MCP-1. The urinary MCP-1 level was significantly higher 
      in patients with micro and macroalbuminuria (167.41 +/- 50.23 and 630.87 +/- 
      318.10 ng/gm creatinine respectively) as compared with normoalbuminuric patients 
      and healthy controls (63.85 +/- 21.15 and 61.50 +/- 24.81 ng/gm creatinine, p p 
      0.001), HbA1c (r= 0.55, p 0.001) and inversely with eGFR (r=-0.60, p< 0.001). Our 
      findings suggest that hyperglycemia is associated with increased urinary levels 
      of MCP-1 that is closely linked to renal damage as reflected by proteinuria and 
      eGFR levels. Collectively, these findings suggest that MCP-1 is involved in the 
      pathogenesis of diabetic nephropathy through its various stages.
FAU - Ibrahim, Salwa
AU  - Ibrahim S
AD  - Department of Internal Medicine, Cairo University, Egypt. 
      salwaibrahim@hotmail.com
FAU - Rashed, Laila
AU  - Rashed L
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Albuminuria/urine
MH  - Chemokine CCL2/*urine
MH  - Diabetes Mellitus, Type 2/*urine
MH  - Diabetic Nephropathies/*urine
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2008/11/01 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/11/01 09:00
PHST- 2008/11/01 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
PHST- 2008/11/01 09:00 [entrez]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2008 Nov;19(6):911-7.