PMID- 18975003
OWN - NLM
STAT- MEDLINE
DCOM- 20090407
LR  - 20211203
IS  - 0932-0113 (Print)
IS  - 0932-0113 (Linking)
VI  - 104
IP  - 3
DP  - 2009 Feb
TI  - Reduced CD3/TCR complex expression leads to immunosuppression during Plasmodium 
      falciparum malaria.
PG  - 575-82
LID - 10.1007/s00436-008-1232-9 [doi]
AB  - Inhibition of T cell function is an important pathological feature in malaria. We 
      investigated which T cell population is reduced contributing to 
      immunosuppression. We examined protein and RNA level of various cell receptors, 
      specific for T cells in children having Plasmodium falciparum infection and 
      compared those to healthy children of the same age. We observe reduced levels of 
      cluster of differentiation (CD)3 and T cell receptor (TCR)alphabeta in both RNA 
      and protein expression level. This reduced expression was associated with a 
      collapsed membrane asymmetry as determined by enhanced annexinV binding. Also 
      human leukocyte antigen (HLA)-A,B,C- and HLA-DR-positive cells increasingly bound 
      annexinV. The enhanced binding of annexinV was paralleled by a reduced expression 
      of transcription factors such as T cell transcription factor 7 and GATA binding 
      protein 3, which are involved in the expression of T cell specific genes. Also 
      the expression of the transcription factors major histocompatibility complex 
      class II transactivator and regulatory factor X 5, which are part of the HLA 
      transcription machinery, is reduced during infection. We show that two mechanisms 
      may lead to a suppression of the immune system during malaria: cell damage and 
      reduction of gene expression of the CD3/TCR complex.
FAU - Kalmbach, Yvonne
AU  - Kalmbach Y
AD  - Department of Parasitology, Institute for Tropical Medicine, University of 
      Tubingen, Wilhelmstr. 27, 72074, Tubingen, Germany.
FAU - Boldt, Angelica B W
AU  - Boldt AB
FAU - Mordmuller, Benjamin
AU  - Mordmuller B
FAU - Kombila, Maryvonne
AU  - Kombila M
FAU - Grobusch, Martin P
AU  - Grobusch MP
FAU - Kremsner, Peter G
AU  - Kremsner PG
FAU - Kun, Jurgen F J
AU  - Kun JF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081031
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Annexin A5)
RN  - 0 (CD3 Complex)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Annexin A5/metabolism
MH  - CD3 Complex/*biosynthesis
MH  - Cell Membrane/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - *Immunosuppression Therapy
MH  - Infant
MH  - Malaria, Falciparum/*immunology
MH  - Plasmodium falciparum/*immunology
MH  - Receptors, Antigen, T-Cell, alpha-beta/*biosynthesis
MH  - Transcription Factors/biosynthesis
EDAT- 2008/11/01 09:00
MHDA- 2009/04/08 09:00
CRDT- 2008/11/01 09:00
PHST- 2008/07/11 00:00 [received]
PHST- 2008/10/09 00:00 [accepted]
PHST- 2008/11/01 09:00 [pubmed]
PHST- 2009/04/08 09:00 [medline]
PHST- 2008/11/01 09:00 [entrez]
AID - 10.1007/s00436-008-1232-9 [doi]
PST - ppublish
SO  - Parasitol Res. 2009 Feb;104(3):575-82. doi: 10.1007/s00436-008-1232-9. Epub 2008 
      Oct 31.