PMID- 18976655
OWN - NLM
STAT- MEDLINE
DCOM- 20090202
LR  - 20220224
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 582
IP  - 28
DP  - 2008 Nov 26
TI  - Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant 
      protein-1 secretion in monocytes/macrophages.
PG  - 3893-8
LID - 10.1016/j.febslet.2008.10.030 [doi]
AB  - We have previously shown that homocysteine (Hcy) can induce monocyte 
      chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in 
      human monocytes. Here, we show that Hcy upregulates expression of an important 
      antioxidative protein, thioredoxin (Trx), via NADPH oxidase in human monocytes in 
      vitro. The increase of Trx expression and activity inhibited Hcy-induced ROS 
      production and MCP-1 secretion. Of note, 2-week hyperhomocysteinemia (HHcy) 
      ApoE(-/-) mice showed accelerated lesion formation and parallel lower Trx 
      expression in macrophages than ApoE(-/-) mice, suggesting that HHcy-induced 
      sustained oxidative stress in vivo might account for impaired Trx and hence 
      increased ROS production and MCP-1 secretion from macrophages, and subsequently 
      accelerated atherogenesis.
FAU - Dai, Jing
AU  - Dai J
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Science, 
      Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry 
      of Education, Beijing 100083, PR China.
FAU - Wang, Xiaofei
AU  - Wang X
FAU - Feng, Juan
AU  - Feng J
FAU - Kong, Wei
AU  - Kong W
FAU - Xu, Qingbo
AU  - Xu Q
FAU - Shen, Xun
AU  - Shen X
FAU - Wang, Xian
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081029
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Apolipoproteins E)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Reactive Oxygen Species)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 52500-60-4 (Thioredoxins)
RN  - EC 1.6.3.- (NADPH Oxidases)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/genetics
MH  - Atherosclerosis/metabolism/pathology
MH  - Cells, Cultured
MH  - Chemokine CCL2/*metabolism
MH  - Homocysteine/*metabolism/pharmacology
MH  - Humans
MH  - Macrophages/drug effects/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Monocytes/drug effects/*metabolism
MH  - NADPH Oxidases/metabolism
MH  - Reactive Oxygen Species
MH  - Thioredoxins/biosynthesis/*physiology
EDAT- 2008/11/04 09:00
MHDA- 2009/02/03 09:00
CRDT- 2008/11/04 09:00
PHST- 2008/10/07 00:00 [received]
PHST- 2008/10/17 00:00 [revised]
PHST- 2008/10/17 00:00 [accepted]
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2009/02/03 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
AID - S0014-5793(08)00848-X [pii]
AID - 10.1016/j.febslet.2008.10.030 [doi]
PST - ppublish
SO  - FEBS Lett. 2008 Nov 26;582(28):3893-8. doi: 10.1016/j.febslet.2008.10.030. Epub 
      2008 Oct 29.