PMID- 18976921
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20191003
IS  - 0966-842X (Print)
IS  - 1878-4380 (Electronic)
IS  - 0966-842X (Linking)
VI  - 16
IP  - 12
DP  - 2008 Dec
TI  - KIR-HLA intercourse in HIV disease.
PG  - 620-7
LID - 10.1016/j.tim.2008.09.002 [doi]
AB  - Human leukocyte antigen (HLA) class I loci are essential to an effective immune 
      response against a wide variety of pathogenic microorganisms, and they represent 
      the prototypes for genetic polymorphism that are sustained through balancing 
      selection. The functional significance of HLA class I variation is better 
      exemplified by studies involving HIV type 1 (HIV-1) than any other infectious 
      organism. HLA class I molecules are essential to the acquired immune response, 
      but they are also important in innate immunity as ligands for the killer cell 
      immunoglobulin-like receptors (KIR), which modulate natural killer cell activity. 
      Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 
      genes, describe the effects of these loci on HIV disease, and discuss questions 
      that remain unresolved.
FAU - Carrington, Mary
AU  - Carrington M
AD  - Cancer and Inflammation Program, Laboratory of Experimental Immunology, 
      SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. 
      carringt@ncifcrf.gov
FAU - Martin, Maureen P
AU  - Martin MP
FAU - van Bergen, Jeroen
AU  - van Bergen J
LA  - eng
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - ZIA BC010791-04/Intramural NIH HHS/United States
GR  - N01-CO-12400/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20081029
PL  - England
TA  - Trends Microbiol
JT  - Trends in microbiology
JID - 9310916
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR3DL1)
RN  - 0 (Receptors, KIR3DS1)
SB  - IM
MH  - Disease Progression
MH  - HIV Infections/immunology/*physiopathology/virology
MH  - HIV-1/*pathogenicity
MH  - HLA Antigens/*metabolism
MH  - HLA-B Antigens/metabolism
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Receptors, KIR/*metabolism
MH  - Receptors, KIR3DL1/metabolism
MH  - Receptors, KIR3DS1/metabolism
PMC - PMC3463869
MID - NIHMS405778
EDAT- 2008/11/04 09:00
MHDA- 2009/02/20 09:00
PMCR- 2012/10/04
CRDT- 2008/11/04 09:00
PHST- 2008/07/14 00:00 [received]
PHST- 2008/09/10 00:00 [revised]
PHST- 2008/09/15 00:00 [accepted]
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
PHST- 2012/10/04 00:00 [pmc-release]
AID - S0966-842X(08)00222-9 [pii]
AID - 10.1016/j.tim.2008.09.002 [doi]
PST - ppublish
SO  - Trends Microbiol. 2008 Dec;16(12):620-7. doi: 10.1016/j.tim.2008.09.002. Epub 
      2008 Oct 29.