PMID- 18977211
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20221207
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 42
IP  - 1-2
DP  - 2009 Jan
TI  - Association between the -2518G/A polymorphism in the monocyte chemoattractant 
      protein-1 (MCP-1) gene and hypertension in Tunisian patients.
PG  - 34-7
LID - 10.1016/j.clinbiochem.2008.09.118 [doi]
AB  - OBJECTIVES: Monocyte chemoattractant protein-1 (MCP-1:CCL2) has been demonstrated 
      to be involved in the pathophysiology of atherosclerosis and hypertension. This 
      study was aimed to investigate whether the single nucleotide polymorphism (SNP) 
      at -2518 of the MCP-1 gene promoter region is associated to hypertension in a 
      sample of Tunisian population. DESIGN AND METHODS: A total of 290 Tunisian 
      patients with hypertension and 390 normotensive controls were included in the 
      study. The SNP of the MCP-1 gene was determined by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: A 
      significant difference in genotype distribution and allele frequency was observed 
      between patients and controls. Patients with hypertension had a frequency of 7.2% 
      for the GG genotype, 35.2% for the AG genotype and 57.6% for the AA genotype. 
      Normotensive subjects had a frequency of 3.6% for the GG genotype, 29.7% for the 
      AG genotype and 66.7% for the AA genotype (chi(2)=8.02, p=0.01). The hypertension 
      patient group showed a significant higher frequency of the G allele compared to 
      the controls [0.24 vs. 0.18; OR (95%CI), 1.46 (1.11-1.91), p=0.004]. The 
      association between the -2518 G/A polymorphism of MCP-1 gene and hypertension 
      remained significant after adjustment for other well-established cardiovascular 
      risk factors. CONCLUSION: The present study showed a significant and independent 
      association between the -2518G/A polymorphism of the MCP-1 gene (presence of G 
      allele) and hypertension in the Tunisian population.
FAU - Jemaa, Riadh
AU  - Jemaa R
AD  - Research Laboratory LR99ES11, Department of Biochemistry, Rabta University 
      Hospital, Tunis, Tunisia. jemaa_riadh@yahoo.fr
FAU - Ben Ali, Samir
AU  - Ben Ali S
FAU - Kallel, Amani
AU  - Kallel A
FAU - Omar, Souheil
AU  - Omar S
FAU - Feki, Moncef
AU  - Feki M
FAU - Elasmi, Monia
AU  - Elasmi M
FAU - Haj-Taieb, Samah
AU  - Haj-Taieb S
FAU - Sanhaji, Haifa
AU  - Sanhaji H
FAU - Kaabachi, Naziha
AU  - Kaabachi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081018
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Black People
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypertension/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics/physiology
MH  - Tunisia
EDAT- 2008/11/04 09:00
MHDA- 2009/04/21 09:00
CRDT- 2008/11/04 09:00
PHST- 2008/06/10 00:00 [received]
PHST- 2008/09/27 00:00 [revised]
PHST- 2008/09/30 00:00 [accepted]
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
AID - S0009-9120(08)00526-2 [pii]
AID - 10.1016/j.clinbiochem.2008.09.118 [doi]
PST - ppublish
SO  - Clin Biochem. 2009 Jan;42(1-2):34-7. doi: 10.1016/j.clinbiochem.2008.09.118. Epub 
      2008 Oct 18.