PMID- 18978208
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 113
IP  - 5
DP  - 2009 Jan 29
TI  - A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma 
      characterized by a predominantly diffuse growth pattern and deletions in the 
      chromosomal region 1p36.
PG  - 1053-61
LID - 10.1182/blood-2008-07-168682 [doi]
AB  - Follicular lymphoma (FL) is a morphologically and genetically well-characterized 
      B-cell non-Hodgkin lymphoma that can show predominantly follicular, combined 
      follicular and diffuse, or predominantly diffuse growth patterns. Although 
      approximately 85% of FLs harbor the translocation t(14;18)(q32;q21) and 
      consistently display a follicular growth pattern, predominantly diffuse FLs are 
      less well characterized on the phenotypical, molecular, and clinical level. We 
      studied 35 predominantly diffuse FL by immunohistochemistry, classical chromosome 
      banding analysis, fluorescence in situ hybridization (FISH), and gene expression 
      profiling. A total of 28 of 29 analyzable cases lacked t(14;18), and 27 of 29 
      cases revealed a unifying chromosomal aberration, a deletion in 1p36. 
      Morphologically, 12 FLs were grade 1 and 23 were grade 2, and the immunophenotype 
      with frequent expression of CD10, BCL6, and CD23 was in line with a germinal 
      center B-cell phenotype. The gene expression profiles of 4 predominantly diffuse 
      FLs fell into the spectrum of typical FL, with a unique enrichment of specific 
      gene signatures. Remarkably, patients with diffuse FL frequently presented with 
      low clinical stage and large but localized inguinal tumors. These results suggest 
      that predominantly diffuse FL represent a distinct subtype of t(14;18)-negative 
      nodal FL with a unifying genetic alteration (deletion of 1p36) and characteristic 
      clinical features.
FAU - Katzenberger, Tiemo
AU  - Katzenberger T
AD  - Department of Pathology, University of Wurzburg, Wurzburg, Germany.
FAU - Kalla, Jorg
AU  - Kalla J
FAU - Leich, Ellen
AU  - Leich E
FAU - Stocklein, Heike
AU  - Stocklein H
FAU - Hartmann, Elena
AU  - Hartmann E
FAU - Barnickel, Sandra
AU  - Barnickel S
FAU - Wessendorf, Swen
AU  - Wessendorf S
FAU - Ott, M Michaela
AU  - Ott MM
FAU - Muller-Hermelink, Hans Konrad
AU  - Muller-Hermelink HK
FAU - Rosenwald, Andreas
AU  - Rosenwald A
FAU - Ott, German
AU  - Ott G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20081031
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Female
MH  - *Gene Expression Regulation, Leukemic
MH  - Germinal Center/metabolism/pathology
MH  - Humans
MH  - Lymphoma, B-Cell/genetics/*metabolism/*pathology
MH  - Lymphoma, Follicular/genetics/*metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*biosynthesis/genetics
MH  - Translocation, Genetic
EDAT- 2008/11/04 09:00
MHDA- 2009/02/28 09:00
CRDT- 2008/11/04 09:00
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
AID - S0006-4971(20)37779-X [pii]
AID - 10.1182/blood-2008-07-168682 [doi]
PST - ppublish
SO  - Blood. 2009 Jan 29;113(5):1053-61. doi: 10.1182/blood-2008-07-168682. Epub 2008 
      Oct 31.