PMID- 18978793
OWN - NLM
STAT- MEDLINE
DCOM- 20081230
LR  - 20210727
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 9
IP  - 12
DP  - 2008 Dec
TI  - Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity 
      against intracellular pathogens.
PG  - 1399-406
LID - 10.1038/ni.1671 [doi]
AB  - Toll-like receptor (TLR) signaling in macrophages is required for antipathogen 
      responses, including the biosynthesis of nitric oxide from arginine, and is 
      essential for immunity to Mycobacterium tuberculosis, Toxoplasma gondii and other 
      intracellular pathogens. Here we report a 'loophole' in the TLR pathway that is 
      advantageous to these pathogens. Intracellular pathogens induced expression of 
      the arginine hydrolytic enzyme arginase 1 (Arg1) in mouse macrophages through the 
      TLR pathway. In contrast to diseases dominated by T helper type 2 responses in 
      which Arg1 expression is greatly increased by interleukin 4 and 13 signaling 
      through the transcription factor STAT6, TLR-mediated Arg1 induction was 
      independent of the STAT6 pathway. Specific elimination of Arg1 in macrophages 
      favored host survival during T. gondii infection and decreased lung bacterial 
      load during tuberculosis infection.
FAU - El Kasmi, Karim C
AU  - El Kasmi KC
AD  - Department of Infectious Diseases, St. Jude Children's Research Hospital, 
      Memphis, Tennessee 38015, USA.
FAU - Qualls, Joseph E
AU  - Qualls JE
FAU - Pesce, John T
AU  - Pesce JT
FAU - Smith, Amber M
AU  - Smith AM
FAU - Thompson, Robert W
AU  - Thompson RW
FAU - Henao-Tamayo, Marcela
AU  - Henao-Tamayo M
FAU - Basaraba, Randall J
AU  - Basaraba RJ
FAU - Konig, Till
AU  - Konig T
FAU - Schleicher, Ulrike
AU  - Schleicher U
FAU - Koo, Mi-Sun
AU  - Koo MS
FAU - Kaplan, Gilla
AU  - Kaplan G
FAU - Fitzgerald, Katherine A
AU  - Fitzgerald KA
FAU - Tuomanen, Elaine I
AU  - Tuomanen EI
FAU - Orme, Ian M
AU  - Orme IM
FAU - Kanneganti, Thirumala-Devi
AU  - Kanneganti TD
FAU - Bogdan, Christian
AU  - Bogdan C
FAU - Wynn, Thomas A
AU  - Wynn TA
FAU - Murray, Peter J
AU  - Murray PJ
LA  - eng
GR  - R01 AI066046/AI/NIAID NIH HHS/United States
GR  - AI062921/AI/NIAID NIH HHS/United States
GR  - P30 CA021765-30/CA/NCI NIH HHS/United States
GR  - AI27913/AI/NIAID NIH HHS/United States
GR  - Intramural NIH HHS/United States
GR  - P30 CA21765/CA/NCI NIH HHS/United States
GR  - R01 AI062921-04/AI/NIAID NIH HHS/United States
GR  - P30 CA021765/CA/NCI NIH HHS/United States
GR  - R01 AI062921/AI/NIAID NIH HHS/United States
GR  - AI66046/AI/NIAID NIH HHS/United States
GR  - R01 AI027913/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081102
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (CCAAT-Enhancer-Binding Protein-beta)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (Toll-Like Receptors)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Animals
MH  - Arginase/*immunology/metabolism
MH  - Bacterial Infections/*immunology
MH  - CCAAT-Enhancer-Binding Protein-beta/immunology/metabolism
MH  - Immunoblotting
MH  - Immunohistochemistry
MH  - Macrophages/*immunology/*microbiology
MH  - Mice
MH  - Mice, Knockout
MH  - Myeloid Differentiation Factor 88/immunology/metabolism
MH  - STAT6 Transcription Factor/immunology/metabolism
MH  - Toll-Like Receptors/*immunology/metabolism
PMC - PMC2584974
MID - NIHMS77639
EDAT- 2008/11/04 09:00
MHDA- 2008/12/31 09:00
PMCR- 2009/06/01
CRDT- 2008/11/04 09:00
PHST- 2008/08/18 00:00 [received]
PHST- 2008/10/01 00:00 [accepted]
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2008/12/31 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
PHST- 2009/06/01 00:00 [pmc-release]
AID - ni.1671 [pii]
AID - 10.1038/ni.1671 [doi]
PST - ppublish
SO  - Nat Immunol. 2008 Dec;9(12):1399-406. doi: 10.1038/ni.1671. Epub 2008 Nov 2.