PMID- 18979107
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20090917
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 301
IP  - 10
DP  - 2009 Oct
TI  - Contribution of itch-associated scratch behavior to the development of skin 
      lesions in Dermatophagoides farinae-induced dermatitis model in NC/Nga mice.
PG  - 739-46
LID - 10.1007/s00403-008-0912-8 [doi]
AB  - Recently, we have reported that the pathophysiological features of dermatitis 
      induced by the repeated application with Dermatophagoides farinae (Df) extract 
      ointment in NC/Nga mice were similar to those observed in the patients with 
      atopic dermatitis. In the present study, we first examined whether the 
      application of Df in other mouse strains could induce dermatitis. The repeated 
      application of Df body (Dfb) ointment to the barrier-disrupted back of ICR, 
      C57BL/6, and Balb/c mice did not cause any apparent skin lesions, although 
      transient increase in serum immunoglobulin E (IgE) levels during antigen 
      application was observed. On the other hand, in NC/Nga mice, dermatitis scores 
      and serum IgE levels increased remarkably, and then these changes sustained for 
      at least 10 days after stopping of antigen elicitation. Using NC/Nga mice, we 
      investigated the contribution of scratching behavior to the development and 
      maintenance of Dfb-induced dermatitis. In correlation with the increase in 
      scratching behavior, erythema, hemorrhage, edema, scarring, erosion and 
      excoriation were observed. Cutting off the hind toenails of mice exhibiting 
      chronic skin lesions dramatically alleviated the dermatitis. From these findings, 
      the onset of skin lesions and its chronically sustained course in Dfb-induced 
      dermatitis in NC/Nga mice were closely associated with increased scratching 
      behavior.
FAU - Yamamoto, Mina
AU  - Yamamoto M
AD  - Discovery Research Laboratory, Shionogi & Co., LTD, Toyonaka, Osaka, Japan.
FAU - Haruna, Takayo
AU  - Haruna T
FAU - Ueda, Chihiro
AU  - Ueda C
FAU - Asano, Yumi
AU  - Asano Y
FAU - Takahashi, Hisashi
AU  - Takahashi H
FAU - Iduhara, Miho
AU  - Iduhara M
FAU - Takaki, Shigeki
AU  - Takaki S
FAU - Yasui, Kiyoshi
AU  - Yasui K
FAU - Matsuo, Yoshiyuki
AU  - Matsuo Y
FAU - Arimura, Akinori
AU  - Arimura A
LA  - eng
PT  - Journal Article
DEP - 20081101
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Cell Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens, Dermatophagoides/administration & dosage/*immunology
MH  - Cell Extracts/administration & dosage
MH  - Dermatitis, Atopic/blood/*immunology/physiopathology
MH  - Dermatophagoides farinae/*immunology
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Female
MH  - Immunization
MH  - Immunoglobulin E/blood/genetics/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Pruritus
MH  - Skin/immunology/*metabolism/pathology
EDAT- 2008/11/04 09:00
MHDA- 2010/03/13 06:00
CRDT- 2008/11/04 09:00
PHST- 2008/05/27 00:00 [received]
PHST- 2008/09/30 00:00 [accepted]
PHST- 2008/09/05 00:00 [revised]
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
AID - 10.1007/s00403-008-0912-8 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2009 Oct;301(10):739-46. doi: 10.1007/s00403-008-0912-8. Epub 
      2008 Nov 1.