PMID- 18979226 OWN - NLM STAT- MEDLINE DCOM- 20091001 LR - 20221207 IS - 1573-4978 (Electronic) IS - 0301-4851 (Linking) VI - 36 IP - 7 DP - 2009 Sep TI - The genetic relationship among Iranian ethnic groups: an anthropological view based on HLA class II gene polymorphism. PG - 1943-50 LID - 10.1007/s11033-008-9403-4 [doi] AB - Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians, Greeks, and Italians. FAU - Farjadian, Shirin AU - Farjadian S AD - Immunology department, Shiraz University of Medical Sciences, Shiraz, Iran. farjadsh@sums.ac.ir FAU - Ota, Massao AU - Ota M FAU - Inoko, Hidetoshi AU - Inoko H FAU - Ghaderi, Abbas AU - Ghaderi A LA - eng PT - Journal Article DEP - 20081102 PL - Netherlands TA - Mol Biol Rep JT - Molecular biology reports JID - 0403234 RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DQ alpha-Chains) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQA1 antigen) RN - 0 (HLA-DQB1 antigen) RN - 0 (HLA-DR Antigens) RN - 0 (Histocompatibility Antigens Class II) SB - IM MH - American Indian or Alaska Native/genetics MH - Asian People/*ethnology/*genetics MH - Black People/genetics MH - Ethnicity/*ethnology/*genetics MH - Gene Frequency MH - HLA-DQ Antigens/genetics MH - HLA-DQ alpha-Chains MH - HLA-DQ beta-Chains MH - HLA-DR Antigens/genetics MH - Histocompatibility Antigens Class II/*genetics MH - Humans MH - Iran MH - Phylogeny MH - *Polymorphism, Genetic MH - White People/genetics EDAT- 2008/11/04 09:00 MHDA- 2009/10/02 06:00 CRDT- 2008/11/04 09:00 PHST- 2008/08/10 00:00 [received] PHST- 2008/10/20 00:00 [accepted] PHST- 2008/11/04 09:00 [pubmed] PHST- 2009/10/02 06:00 [medline] PHST- 2008/11/04 09:00 [entrez] AID - 10.1007/s11033-008-9403-4 [doi] PST - ppublish SO - Mol Biol Rep. 2009 Sep;36(7):1943-50. doi: 10.1007/s11033-008-9403-4. Epub 2008 Nov 2.