PMID- 18979354
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20081103
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 72
IP  - 1
DP  - 2009
TI  - Concentration and persistence of tin in rat brain and blood following dibutyltin 
      exposure during development.
PG  - 47-52
LID - 10.1080/15287390802445582 [doi]
AB  - Dibutyltin (DBT), a widely used plastic stabilizer, has been detected in the 
      environment as well as human tissues. Although teratological and developmental 
      effects are well documented, there are no published reports of DBT effects on the 
      developing nervous system. As part of a developmental neurotoxicity study of DBT, 
      tissue samples were periodically collected to determine the distribution of total 
      tin (Sn) in brain and whole blood. Pregnant Sprague-Dawley rats were exposed to 
      0, 10, or 25 ppm DBT in drinking water from gestational day (GD) 6 to weaning at 
      postnatal day (PND) 21. Beginning on PND 3, half of the litters were directly 
      dosed every 2 to 3 d via oral gavage with 0, 1, or 2.5 mg/kg DBT such that the 
      dose level matched the water concentration (for example, litters with 25 ppm DBT 
      in the water received 2.5 mg/kg). For Sn analysis, brain and blood samples were 
      collected from culled pups on PND2 (males and females pooled), from pups (males 
      and females separately) as well as dams at weaning (PND21), and from adult 
      offspring (males and females) at PND93. Total Sn was quantified using inductively 
      coupled plasma-mass spectroscopy (ICP-MS). At all ages, brain Sn levels were 
      higher than blood. At culling, in the directly dosed pups at weaning, and in dams 
      at weaning, Sn levels in both tissues were linearly related to dose. Weanling 
      pups without direct dosing showed lower levels than either culled pups or dams, 
      indicating that lactational exposure was minimal or negligible even while 
      maternal exposure is ongoing. In the adults, Sn levels persisted in brains of 
      directly dosed rats, and the high-dose females had higher levels than did 
      high-dose males. No Sn was detected in adult blood. Thus, during maternal 
      exposure to DBT in drinking water, Sn is placentally transferred to the 
      offspring, but lactational transfer is minimal, if any. Furthermore, Sn is 
      concentrated in brain compared to blood, and its elimination is protracted, on 
      the order of days to months after exposure ends.
FAU - Moser, V C
AU  - Moser VC
AD  - Neurotoxicology Division, National Health and Environmental Effects Research 
      Laboratory, US Environmental Protection Agency, Research Triangle Park, North 
      Carolina 27711, USA. Moser.ginger@epa.gov
FAU - McGee, J K
AU  - McGee JK
FAU - Ehman, K D
AU  - Ehman KD
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organotin Compounds)
RN  - 1002-53-5 (di-n-butyltin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Animals, Newborn/*blood
MH  - Brain/embryology/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/*pharmacokinetics/toxicity
MH  - Female
MH  - Lactation/drug effects/physiology
MH  - Male
MH  - Maternal Exposure
MH  - Maternal-Fetal Exchange/*drug effects/physiology
MH  - Organotin Compounds/*pharmacokinetics/toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
EDAT- 2008/11/04 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/11/04 09:00
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
AID - 905011822 [pii]
AID - 10.1080/15287390802445582 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2009;72(1):47-52. doi: 10.1080/15287390802445582.