PMID- 18979374
OWN - NLM
STAT- MEDLINE
DCOM- 20090519
LR  - 20131121
IS  - 0036-5599 (Print)
IS  - 0036-5599 (Linking)
VI  - 43
IP  - 2
DP  - 2009
TI  - Long-term treatment results and the immunoglobulin G subclass distribution 
      patterns of proteinase-3-antineutrophil cytoplasm antibody (ANCA) and 
      myeloperoxidase-ANCA in ANCA-associated vasculitis.
PG  - 160-70
LID - 10.1080/00365590802519354 [doi]
AB  - OBJECTIVE: Small vessel vasculitis associated with antibodies to neutrophil 
      cytoplasm antigens has been denominated antineutrophil cytoplasm antibody 
      (ANCA)-associated vasculitis (AAV). MATERIAL AND METHODS: Ninety-eight patients 
      with various forms of AAV with renal involvement were studied retrospectively 
      with regard to treatment, side-effects and outcome. The immunoglobulin G (IgG) 
      subclass distribution patterns in serum were determined in 51 patients with 
      nephelometry and those of anti-proteinase-3 (PR3) and anti-myeloperoxidase (MPO) 
      in 44 patients by enzyme-linked immunosorbent assay. RESULTS: Fifty-nine patients 
      with a mean age of 63 years were given treatment with intermittent intravenous 
      regimens of cyclophosphamide and continuous corticosteroids, whereas 39 patients 
      with a mean age of 58 years were given continuous oral treatment. Malignancy, 
      mainly due to skin tumours, was more common in AAV than in the general 
      population. The total IgG subclass distribution pattern was asymmetric. The 
      response to PR3 was of IgG(1), IgG(3) and IgG(4) isotypes, while IgG(1) and 
      IgG(3) predominated in the response to MPO. CONCLUSION: The aberrant IgG subclass 
      distribution pattern detected in the autoantibodies may be of importance in the 
      pathogenesis of AAV.
FAU - Almroth, Gabriel
AU  - Almroth G
AD  - Departments of Nephrology, University Hospital, Linkoping, Sweden. 
      gabriel.almroth@lio.se
FAU - Berlin, Gosta
AU  - Berlin G
FAU - Andersson, Bengt
AU  - Andersson B
FAU - Hahn-Zoric, Mirjana
AU  - Hahn-Zoric M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Urol Nephrol
JT  - Scandinavian journal of urology and nephrology
JID - 0114501
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunologic Factors)
RN  - 0 (Immunosuppressive Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.21.76 (Myeloblastin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Cyclophosphamide/administration & dosage
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Immunologic Factors/*immunology
MH  - Immunosuppressive Agents/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Myeloblastin/immunology
MH  - Peroxidase/immunology
MH  - Plasma Exchange
MH  - Remission Induction
MH  - Treatment Outcome
MH  - Vasculitis/*immunology/mortality
EDAT- 2008/11/04 09:00
MHDA- 2009/05/20 09:00
CRDT- 2008/11/04 09:00
PHST- 2008/11/04 09:00 [pubmed]
PHST- 2009/05/20 09:00 [medline]
PHST- 2008/11/04 09:00 [entrez]
AID - 905011261 [pii]
AID - 10.1080/00365590802519354 [doi]
PST - ppublish
SO  - Scand J Urol Nephrol. 2009;43(2):160-70. doi: 10.1080/00365590802519354.