PMID- 1897967
OWN - NLM
STAT- MEDLINE
DCOM- 19911024
LR  - 20190628
IS  - 0003-9861 (Print)
IS  - 0003-9861 (Linking)
VI  - 286
IP  - 2
DP  - 1991 May 1
TI  - Cysteine sulfinic acid decarboxylase activity in response to thyroid hormone 
      administration in rats.
PG  - 428-32
AB  - The modulation of hepatic and renal cysteine sulfinic acid decarboxylase (EC 
      4.1.1.29) activities by triiodothyronine (T3) was studied in a series of 
      experiments. In a dose--response study, hepatic cysteine sulfinic acid 
      decarboxylase activity (CSAD) was depressed by 65% and renal activity was 
      increased threefold in rats injected with 100 micrograms T3/100 g body wt for 7 
      days when compared to rats injected with 0.3 micrograms T3/100 g body wt. Western 
      blot analysis indicated that these changes in CSAD activity were due to changes 
      in the quantity of CSAD protein. Changes in hepatic and renal activities were not 
      evident until 24 h after T3 administration. In response to T3 clearance, hepatic 
      and renal CSAD activities approached euthyroid values 4-7 days after cessation of 
      T3 injections although serum T3 concentrations were no different from euthyroid 
      values 48 h after T3 injections were stopped. These data indicate that thyroid 
      hormone effects persist after T3 clearance. The response of CSAD to thyroid 
      status may be related to its role in taurine biosynthesis.
FAU - Jerkins, A A
AU  - Jerkins AA
AD  - Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
FAU - Steele, R D
AU  - Steele RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Biochem Biophys
JT  - Archives of biochemistry and biophysics
JID - 0372430
RN  - EC 4.1.1.- (Carboxy-Lyases)
RN  - EC 4.1.1.29 (sulfoalanine decarboxylase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Carboxy-Lyases/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Kidney/drug effects/*enzymology
MH  - Kinetics
MH  - Liver/drug effects/*enzymology
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Thyroxine/blood/pharmacokinetics/*pharmacology
MH  - Time Factors
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 0003-9861(91)90061-M [pii]
AID - 10.1016/0003-9861(91)90061-m [doi]
PST - ppublish
SO  - Arch Biochem Biophys. 1991 May 1;286(2):428-32. doi: 
      10.1016/0003-9861(91)90061-m.