PMID- 18981650
OWN - NLM
STAT- MEDLINE
DCOM- 20090121
LR  - 20220318
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 15
IP  - 5
DP  - 2008 Oct
TI  - Small LDL-cholesterol is superior to LDL-cholesterol for determining severe 
      coronary atherosclerosis.
PG  - 250-60
AB  - AIM: Recent evidence suggests that small dense low-density lipoprotein (sd-LDL) 
      particles are more atherogenic than large-LDL in spite of their lower cholesterol 
      content. This study aimed to determine whether sd-LDL-cholesterol (sd-LDL-C) is 
      superior to LDL-C as a biomarker of coronary heart disease (CHD). METHODS: LDL 
      particle size determined by gradient gel electrophoresis and sd-LDL-C 
      concentrations quantified by heparin-magnesium precipitation were compared 
      between 482 stable CHD patients and 389 non-diabetic subjects without CHD who 
      were not receiving any lipid-lowering drugs. RESULTS: Both male and female CHD 
      patients had significantly smaller LDL particles and lower large-LDL-C 
      concentrations (estimated by subtracting the sd-LDL-C concentration from the 
      LDL-C concentration), and significantly higher sd-LDL-C concentrations than the 
      control subjects. LDL-C concentrations were modestly higher and sd-LDL-C 
      concentrations were significantly higher in 258 patients with angiographically 
      documented severe CHD than in the patients with mild CHD irrespective of 
      treatment by LDL-lowering drugs and history of myocardial infarction and/or 
      coronary revascularization. Large-LDL-C concentrations, in contrast, were similar 
      between the two groups. Multivariate logistic regression analysis revealed that 
      sd-LDL-C levels were significantly associated with severe CHD independently of 
      LDL-C. CONCLUSION: sd-LDL-C levels are more powerful than LDL-C levels for the 
      determination of severe stable CHD.
FAU - Koba, Shinji
AU  - Koba S
AD  - Department of Medicine, Division of Cardiology, Showa University School of 
      Medicine, tokyo, Japan. skoba@med.showa-u.ac.jp
FAU - Yokota, Yuuya
AU  - Yokota Y
FAU - Hirano, Tsutomu
AU  - Hirano T
FAU - Ito, Yasuki
AU  - Ito Y
FAU - Ban, Yoshihisa
AU  - Ban Y
FAU - Tsunoda, Fumiyoshi
AU  - Tsunoda F
FAU - Sato, Takatoshi
AU  - Sato T
FAU - Shoji, Makoto
AU  - Shoji M
FAU - Suzuki, Hiroshi
AU  - Suzuki H
FAU - Geshi, Eiichi
AU  - Geshi E
FAU - Kobayashi, Youichi
AU  - Kobayashi Y
FAU - Katagiri, Takashi
AU  - Katagiri T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cholesterol, LDL/*blood
MH  - Coronary Artery Disease/blood/*diagnosis
MH  - Coronary Disease/blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Particle Size
EDAT- 2008/11/05 09:00
MHDA- 2009/01/22 09:00
CRDT- 2008/11/05 09:00
PHST- 2008/11/05 09:00 [pubmed]
PHST- 2009/01/22 09:00 [medline]
PHST- 2008/11/05 09:00 [entrez]
AID - JST.JSTAGE/jat/E572 [pii]
AID - 10.5551/jat.e572 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2008 Oct;15(5):250-60. doi: 10.5551/jat.e572.