PMID- 18982372
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20181113
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 13
IP  - 2
DP  - 2009 May
TI  - Sleep in bipolar patients.
PG  - 169-73
LID - 10.1007/s11325-008-0215-5 [doi]
AB  - BACKGROUND: Sleep disturbance has been described in bipolar disorder (BPD). 
      Specific complaints may include frequent nighttime awakenings, poor quality of 
      sleep, reduction in total sleep time, and nightmares. Most patients with BPD also 
      report insomnia when in depression, but a significant percentage of patients 
      report hypersomnia symptoms with prolonged nighttime sleep, difficulty in 
      wakening, and excessive daytime sleepiness. OBJECTIVES: The present study aims to 
      investigate whether bipolar patients with sleep disorders presented impairment in 
      quality of life, disability, and global function. METHODS: One hundred ninety 
      bipolar patients type-I diagnosed by application of Structured Clinician 
      Interview for DSM-IV Disorders (SCID), were distributed in two groups based on 
      absence or presence of sleep disorders. Quality of life, disability, and global 
      dysfunction were evaluated using the Health Organization's Quality of Life 
      instrument (WHOQOL-Brief), the Sheehan Disability Scale, and the Global 
      Assessment of Functioning (GAF), respectively. RESULTS: Sleep complaints have 
      negative influence on general quality of life, observed by decreased scores in 
      WHOQOL and GAF domains and increased Sheehan scores, indicating the importance of 
      maintenance of normal sleep in bipolar patients. CONCLUSION: Our results suggest 
      that sleep complains impair quality of life and global function. Collectively, 
      further studies are warranted to investigate the impairment of sleep disturbance 
      on others neurotrophic factors and neurochemical pathways.
FAU - Giglio, Larriany M F
AU  - Giglio LM
AD  - Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, RS, Brazil. 
      larriany@terra.com.br
FAU - Andreazza, Ana C
AU  - Andreazza AC
FAU - Andersen, Monica
AU  - Andersen M
FAU - Cereser, Keila M
AU  - Cereser KM
FAU - Walz, Julio C
AU  - Walz JC
FAU - Sterz, Laura
AU  - Sterz L
FAU - Kapczinski, Flavio
AU  - Kapczinski F
LA  - eng
PT  - Journal Article
DEP - 20081104
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/blood/diagnosis/*epidemiology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - CREB-Binding Protein/blood
MH  - Cyclic AMP/blood
MH  - Disability Evaluation
MH  - Disorders of Excessive Somnolence/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuronal Plasticity
MH  - Quality of Life/psychology
MH  - Severity of Illness Index
MH  - Sleep Wake Disorders/*diagnosis/*epidemiology
MH  - Surveys and Questionnaires
MH  - Wakefulness
EDAT- 2008/11/05 09:00
MHDA- 2009/11/18 06:00
CRDT- 2008/11/05 09:00
PHST- 2008/04/16 00:00 [received]
PHST- 2008/08/04 00:00 [accepted]
PHST- 2008/07/28 00:00 [revised]
PHST- 2008/11/05 09:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
PHST- 2008/11/05 09:00 [entrez]
AID - 10.1007/s11325-008-0215-5 [doi]
PST - ppublish
SO  - Sleep Breath. 2009 May;13(2):169-73. doi: 10.1007/s11325-008-0215-5. Epub 2008 
      Nov 4.