PMID- 18983581
OWN - NLM
STAT- MEDLINE
DCOM- 20090121
LR  - 20151119
IS  - 0914-3505 (Print)
IS  - 0914-3505 (Linking)
VI  - 48
IP  - 4
DP  - 2008 Dec
TI  - Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) on 
      somatic growth and endocrine status in rat offspring.
PG  - 151-7
LID - 10.1111/j.1741-4520.2008.00199.x [doi]
AB  - Exposure to polychlorobiphenyl (PCB) mixtures at an early stage of development 
      has been reported to affect endocrine glands; however, little is known about the 
      precise toxicological properties of individual PCB. The present study was 
      undertaken to determine whether prenatal exposure to 
      2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153), a di-ortho-substituted non-coplanar 
      congener, affects postnatal development in rat offspring. Pregnant Sprague-Dawley 
      rats (Crj: CD (SD) IGS) were given PCB 153 (0, 16, or 64 mg/kg/day) orally from 
      gestational day (GD) 10 through GD 16, and developmental parameters in the male 
      and female offspring were examined. We found no dose-dependent changes in body 
      weight, body length (nose-anus length), tail length, or the weights of kidneys, 
      testes, ovaries and uterus in offspring at 1 or 3 weeks of age. Liver weights 
      were increased in the PCB 153-treated groups, although we observed a significant 
      difference only in males. Anogenital distance was unaffected in the PCB 
      153-treated groups. We observed a significant dose-dependent decrease in the 
      plasma concentrations of thyroxine and tri-iodothyronine, whereas those of 
      thyroid-stimulating hormone were not significantly changed. In addition, there 
      were no dose-dependent changes in plasma concentrations of growth hormone and 
      insulin-like growth factor-I in any dose group. These findings suggest that 
      prenatal exposure to PCB 153 (GD 10-16, 16-64 mg/kg/day) may alter the thyroid 
      status in rat offspring to some extent without affecting somatic growth or its 
      related hormonal parameters.
FAU - Kobayashi, Kenichi
AU  - Kobayashi K
AD  - National Institute of Occupational Safety and Health, Kawasaki, Japan. 
      kobayasi@h.jniosh.go.jp
FAU - Miyagawa, Muneyuki
AU  - Miyagawa M
FAU - Wang, Rui-Sheng
AU  - Wang RS
FAU - Suda, Megumi
AU  - Suda M
FAU - Sekiguchi, Soichiro
AU  - Sekiguchi S
FAU - Honma, Takeshi
AU  - Honma T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Congenit Anom (Kyoto)
JT  - Congenital anomalies
JID - 9306292
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-71-5 (Thyrotropin)
RN  - 9002-72-6 (Growth Hormone)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - Q51BO43MG4 (Thyroxine)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Female
MH  - Growth Hormone/blood/drug effects
MH  - Insulin-Like Growth Factor I/drug effects/metabolism
MH  - Male
MH  - Organ Size/*drug effects
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thyrotropin/blood/drug effects
MH  - Thyroxine/blood/drug effects
MH  - Triiodothyronine/blood/drug effects
EDAT- 2008/11/06 09:00
MHDA- 2009/01/22 09:00
CRDT- 2008/11/06 09:00
PHST- 2008/11/06 09:00 [pubmed]
PHST- 2009/01/22 09:00 [medline]
PHST- 2008/11/06 09:00 [entrez]
AID - CGA199 [pii]
AID - 10.1111/j.1741-4520.2008.00199.x [doi]
PST - ppublish
SO  - Congenit Anom (Kyoto). 2008 Dec;48(4):151-7. doi: 
      10.1111/j.1741-4520.2008.00199.x.