PMID- 18984437
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20181113
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Print)
IS  - 1052-3057 (Linking)
VI  - 17
IP  - 6
DP  - 2008 Nov-Dec
TI  - Association of carotid artery atherosclerosis with circulating biomarkers of 
      extracellular matrix remodeling: the Framingham Offspring Study.
PG  - 412-7
LID - 10.1016/j.jstrokecerebrovasdis.2008.06.002 [doi]
AB  - OBJECTIVE: We sought to relate circulating biomarkers of extracellular matrix 
      turnover to site-specific measures of carotid artery atherosclerosis on duplex 
      ultrasound. BACKGROUND: Matrix metalloproteinases (MMPs) and tissue inhibitors of 
      MMPs (TIMPs) regulate extracellular matrix remodeling, a key feature of 
      atherosclerosis, and their circulating concentrations can be assayed. MMP-9, 
      TIMP-1, and protocollagen-III n-terminal propeptide (PIIINP) may relate 
      differentially to the severity of atherosclerosis at different carotid artery 
      sites. However, data examining this premise are sparse. METHODS: We related 
      circulating MMP-9, TIMP-1, and/or PIIINP concentrations to carotid 
      atherosclerosis on duplex ultrasound in 1006 Framingham offspring (mean age 58 
      years, 56% women) who attended a routine examination from 1995 to 1998. We used 
      multivariable regression to relate MMP-9 (detectable v undetectable), TIMP-1, and 
      PIIINP (age- and sex-specific quartiles) to internal carotid artery (IC) stenosis 
      (>25%) and log-transformed common carotid artery and IC intima-media thickness 
      (IMT). RESULTS: Detectable MMP-9 was associated with carotid stenosis (odds ratio 
      [OR] 1.71, P = .032) but not with IMT. Higher TIMP-1 was associated with carotid 
      stenosis (OR for Quartiles (Q)4 v Q1-3, 1.63, P = .022) and a higher IC IMT (beta 
      0.057 +/- 0.025, Q4 v Q1-3, P = .023). Higher PIIINP (Q4 v Q1-3) showed a 
      borderline association with carotid stenosis (OR 1.45 for Q4 v Q1-3, P = .095) 
      but not with IMT. TIMP-1 was not associated with common carotid artery IMT. 
      CONCLUSIONS: In our community-based sample of middle-aged to older adults, higher 
      circulating biomarkers of matrix remodeling were associated with a greater 
      prevalence of carotid stenosis and subclinical atherosclerosis in the IC. Our 
      findings are consistent with regional differences in matrix remodeling in the 
      carotid artery.
FAU - Romero, Jose R
AU  - Romero JR
AD  - Department of Neurology, School of Medicine, Boston University, Boston, 
      Massachusetts 02118-2526, USA.
FAU - Vasan, Ramachandran S
AU  - Vasan RS
FAU - Beiser, Alexa S
AU  - Beiser AS
FAU - Polak, Joseph F
AU  - Polak JF
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
FAU - Wolf, Philip A
AU  - Wolf PA
FAU - Seshadri, Sudha
AU  - Seshadri S
LA  - eng
GR  - #N01-HC-25195/HC/NHLBI NIH HHS/United States
GR  - R01 NS017950/NS/NINDS NIH HHS/United States
GR  - R01 AG016495/AG/NIA NIH HHS/United States
GR  - R01 AG016495-09/AG/NIA NIH HHS/United States
GR  - R01 HL067288-04/HL/NHLBI NIH HHS/United States
GR  - N01 HC025195/HC/NHLBI NIH HHS/United States
GR  - 2K24HL04334/HL/NHLBI NIH HHS/United States
GR  - NS17950/NS/NINDS NIH HHS/United States
GR  - AG08122/AG/NIA NIH HHS/United States
GR  - K24 HL004334/HL/NHLBI NIH HHS/United States
GR  - R01 AG008122/AG/NIA NIH HHS/United States
GR  - R01 NS017950-27/NS/NINDS NIH HHS/United States
GR  - R01 HL067288/HL/NHLBI NIH HHS/United States
GR  - K24 HL004334-08/HL/NHLBI NIH HHS/United States
GR  - R01 AG008122-19/AG/NIA NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
GR  - AG16495/AG/NIA NIH HHS/United States
GR  - HL67288/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (procollagen Type III-N-terminal peptide)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Carotid Arteries/diagnostic imaging/*enzymology
MH  - Carotid Stenosis/*blood/*diagnosis/diagnostic imaging
MH  - Cohort Studies
MH  - Disease Progression
MH  - Extracellular Matrix/*enzymology
MH  - Female
MH  - Humans
MH  - Intracranial Arteriosclerosis/*blood/*diagnosis/diagnostic imaging
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Procollagen/blood
MH  - Prognosis
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Tunica Media/diagnostic imaging/enzymology/pathology
MH  - Ultrasonography
PMC - PMC2613480
MID - NIHMS78135
COIS- Disclosure: The authors report no conflicts of interest.
EDAT- 2008/11/06 09:00
MHDA- 2009/02/20 09:00
PMCR- 2009/11/01
CRDT- 2008/11/06 09:00
PHST- 2008/03/27 00:00 [received]
PHST- 2008/06/08 00:00 [revised]
PHST- 2008/06/09 00:00 [accepted]
PHST- 2008/11/06 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/11/06 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - S1052-3057(08)00141-9 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2008.06.002 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2008 Nov-Dec;17(6):412-7. doi: 
      10.1016/j.jstrokecerebrovasdis.2008.06.002.