PMID- 18985097
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20181113
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 1
IP  - 1
DP  - 2006 Jun
TI  - Medial prefrontal activity differentiates self from close others.
PG  - 18-25
LID - 10.1093/scan/nsl001 [doi]
AB  - A key question in psychology and neuroscience is the extent to which the neural 
      representation of others is incorporated with, or is distinct from, our concept 
      of self. Recent neuroimaging research has emphasized the importance of a region 
      in the medial prefrontal cortex [MPFC; Brodmann's area (BA) 10] when performing 
      self-referent tasks. Specifically, previous studies have reported selective MPFC 
      recruitment when making judgments about the self relative to a familiar but 
      personally unknown other. The present event-related functional magnetic resonance 
      imaging study extends these findings to judgments about personally known others. 
      Subjects were imaged while making trait adjective judgments in one of the three 
      conditions: (i) whether the adjective described the self; (ii) whether the 
      adjective described an intimate other (i.e., a best friend); or (iii) whether the 
      adjective was presented in uppercase letters. Making judgments about the self 
      relative to an intimate other selectively activated the MPFC region previously 
      implicated in the self-processing literature. These results suggest that while we 
      may incorporate intimate others into our self-concept, the neural correlates of 
      the self remain distinct from intimate and non-intimate others.
FAU - Heatherton, Todd F
AU  - Heatherton TF
AD  - Department of Psychological and Brain Sciences, Center for Social Brain Sciences, 
      Dartmouth College, Hanover, New Hampshire, USA. todd.heatherton@dartmouth.edu
FAU - Wyland, Carrie L
AU  - Wyland CL
FAU - Macrae, C Neil
AU  - Macrae CN
FAU - Demos, Kathryn E
AU  - Demos KE
FAU - Denny, Bryan T
AU  - Denny BT
FAU - Kelley, William M
AU  - Kelley WM
LA  - eng
GR  - R01 MH059282/MH/NIMH NIH HHS/United States
GR  - R21 MH066720/MH/NIMH NIH HHS/United States
GR  - 1R01MH59282/MH/NIMH NIH HHS/United States
GR  - 1R21MH66720/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prefrontal Cortex/*physiology
MH  - *Self Concept
MH  - *Social Perception
MH  - Young Adult
PMC - PMC2555408
EDAT- 2008/11/06 09:00
MHDA- 2010/06/24 06:00
PMCR- 2006/06/01
CRDT- 2008/11/06 09:00
PHST- 2006/02/15 00:00 [received]
PHST- 2006/03/22 00:00 [accepted]
PHST- 2008/11/06 09:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
PHST- 2008/11/06 09:00 [entrez]
PHST- 2006/06/01 00:00 [pmc-release]
AID - 10.1093/scan/nsl001 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2006 Jun;1(1):18-25. doi: 10.1093/scan/nsl001.