PMID- 18987242
OWN - NLM
STAT- MEDLINE
DCOM- 20081231
LR  - 20190522
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 20
IP  - 6
DP  - 2008 Nov
TI  - Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma.
PG  - 836-8
AB  - A gemistocytic astrocytoma is described in the spinal cord of a 3-year-old, 
      spayed, female, Domestic Shorthair cat. The neoplasm was tested for glial 
      fibrillar acidic protein (GFAP), epidermal growth factor receptor (EGFR), and p53 
      protein expression. On histologic examination, the neoplastic cells were 
      pleomorphic, with distinct cell borders and abundant cytoplasm that frequently 
      extended into variably sized fibrillar processes. Neoplastic cells were strongly 
      positive for GFAP and negative for EGFR. Eight percent (mean percentage) of 
      neoplastic cells were p53 positive. Only 1 p53-positive cell was found in the 
      normal spinal cord. The increased expression of p53 in the neoplasm was 
      suggestive of an abnormal biological behavior of the p53 protein and its possible 
      involvement in the neoplastic process of feline astrocytoma.
FAU - Aloisio, Fabio
AU  - Aloisio F
AD  - Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M 
      University, College Station, TX 77843-4467, USA. faloisio@cvm.tamu.edu
FAU - Levine, Jonathan M
AU  - Levine JM
FAU - Edwards, John F
AU  - Edwards JF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - Animals
MH  - Astrocytes/pathology
MH  - Astrocytoma/pathology/*veterinary
MH  - Cat Diseases/*pathology
MH  - Cats
MH  - Euthanasia
MH  - Female
MH  - Spinal Cord/pathology
MH  - Spinal Cord Neoplasms/pathology/*veterinary
EDAT- 2008/11/07 09:00
MHDA- 2009/01/01 09:00
CRDT- 2008/11/07 09:00
PHST- 2008/11/07 09:00 [pubmed]
PHST- 2009/01/01 09:00 [medline]
PHST- 2008/11/07 09:00 [entrez]
AID - 20/6/836 [pii]
AID - 10.1177/104063870802000624 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 2008 Nov;20(6):836-8. doi: 10.1177/104063870802000624.