PMID- 1898745
OWN - NLM
STAT- MEDLINE
DCOM- 19910212
LR  - 20190820
IS  - 0022-1422 (Print)
IS  - 0022-1422 (Linking)
VI  - 46
IP  - 1
DP  - 1991 Jan
TI  - Caloric restriction affects liver microsomal monooxygenases differentially in 
      aging male rats.
PG  - B23-7
AB  - Caloric restriction (CR) extends life span and retards the onset of physiological 
      changes and pathologies associated with aging, but the underlying mechanisms 
      remain unresolved. This study demonstrates that CR postpones the documented 
      age-related declines in and/or enhances the activity and microsomal concentration 
      of several liver monooxygenases in male rats, i.e., NADPH cytochrome P-450 
      reductase, total cytochromes P-450. However, the relative concentration of 
      cytochrome P-450b+C did not exhibit statistically significant changes, whereas 
      another isozyme, the male specific P-450h, declined significantly in both ad 
      libitum-fed and CR rats as a function of increasing age. While CR appears to 
      retard age-associated changes in certain liver enzymes, this effect is by no 
      means universal. The hepatic monooxygenases constitute a well-characterized 
      enzyme system in which to examine the perturbation of the aging process by CR.
FAU - Schmucker, D L
AU  - Schmucker DL
AD  - Cell Biology and Aging Section VA Medical Center, San Francisco, CA 94121.
FAU - Wang, R K
AU  - Wang RK
FAU - Snyder, D
AU  - Snyder D
FAU - Strobel, H
AU  - Strobel H
FAU - Marti, U
AU  - Marti U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Gerontol
JT  - Journal of gerontology
JID - 0374762
RN  - 0 (Proteins)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.6.2.4 (NADPH-Ferrihemoprotein Reductase)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Cytochrome P-450 Enzyme System/analysis/*metabolism
MH  - *Energy Intake
MH  - Intracellular Membranes/chemistry
MH  - Male
MH  - Microsomes, Liver/chemistry/*enzymology
MH  - NADPH-Ferrihemoprotein Reductase/analysis/*metabolism
MH  - Proteins/analysis
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1093/geronj/46.1.b23 [doi]
PST - ppublish
SO  - J Gerontol. 1991 Jan;46(1):B23-7. doi: 10.1093/geronj/46.1.b23.