PMID- 18989629
OWN - NLM
STAT- MEDLINE
DCOM- 20090805
LR  - 20221207
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 322
IP  - 1-2
DP  - 2009 Feb
TI  - The manganese superoxide dismutase Val16Ala polymorphism is associated with 
      decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes.
PG  - 87-91
LID - 10.1007/s11010-008-9943-x [doi]
AB  - The aim of the present study was to evaluate the relationship of the manganese 
      superoxide dismutase (MnSOD) Val16Ala (V16A) polymorphism with type 2 diabetes 
      mellitus (T2DM) and diabetic nephropathy (DN) in Chinese patients, a case-control 
      study was performed. This case-control study included 172 non-diabetic (non-DM) 
      subjects and 257 T2DM patients with or without DN. Among T2DM patients, 154 had 
      DN [albumin excretion rate (AER) >or= 30 mg/24 h] and 103 did not (AER < 30 mg/24 
      h), but the latter with known diabetes duration >or=10 years. The DN patients 
      were further divided into groups with microalbuminuria (DN-1; n = 92; 300 > AER 
      >or= 30 mg/24 h) and overt albuminuria nephropathy (DN-2; n = 62; AER >or= 300 
      mg/24 h). PCR-restriction fragment length polymorphism (RFLP) was used to detect 
      genotypes of the V16A polymorphism for all subjects. The genotypic distributions 
      of the V16A polymorphism in non-DM and T2DM subjects were in Hardy-Weinberg 
      equilibrium and Ala allelic frequencies did not differ (11.9% vs. 9.1%; P > 
      0.05). The AA+VA genotypic frequencies of DN patients were significantly lower 
      than those of non-DN patients (11.6% vs. 24.3%; P = 0.008). Multiple logistic 
      regression analysis revealed that except for HbA1C, triglyceride, and BMI, which 
      were high risk factors for the development of DN, the AA+VA genotype of the 
      MnSOD-V16A polymorphism was an independent protective factor from the development 
      of DN (odds ratio = 0.42; 95% CI = 0.18-0.95; P = 0.037) in T2DM patients. Our 
      results suggested that the MnSOD-V16A polymorphism is associated with decreased 
      risk of diabetic nephropathy in Chinese patients with type 2 diabetes.
FAU - Liu, Limei
AU  - Liu L
AD  - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai 
      Jiaotong University Affiliated Sixth People's Hospital, 600 Yishan Road, 
      Shanghai, 200233, China. liulimei2001@hotmail.com
FAU - Zheng, Taishan
AU  - Zheng T
FAU - Wang, Niansong
AU  - Wang N
FAU - Wang, Feng
AU  - Wang F
FAU - Li, Ming
AU  - Li M
FAU - Jiang, Jiamei
AU  - Jiang J
FAU - Zhao, Ruie
AU  - Zhao R
FAU - Li, Lifang
AU  - Li L
FAU - Zhao, Weijing
AU  - Zhao W
FAU - Zhu, Qihan
AU  - Zhu Q
FAU - Jia, Weiping
AU  - Jia W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081107
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - HG18B9YRS7 (Valine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Aged
MH  - Alanine/*genetics
MH  - Alleles
MH  - Asian People
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/complications/enzymology/*genetics
MH  - Diabetic Nephropathies/enzymology/etiology/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Risk
MH  - Superoxide Dismutase/*genetics
MH  - Valine/*genetics
EDAT- 2008/11/08 09:00
MHDA- 2009/08/06 09:00
CRDT- 2008/11/08 09:00
PHST- 2008/07/23 00:00 [received]
PHST- 2008/10/22 00:00 [accepted]
PHST- 2008/11/08 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
PHST- 2008/11/08 09:00 [entrez]
AID - 10.1007/s11010-008-9943-x [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2009 Feb;322(1-2):87-91. doi: 10.1007/s11010-008-9943-x. Epub 
      2008 Nov 7.