PMID- 18991141
OWN - NLM
STAT- MEDLINE
DCOM- 20090603
LR  - 20081127
IS  - 1464-5203 (Electronic)
IS  - 0968-7688 (Linking)
VI  - 25
IP  - 8
DP  - 2008 Dec
TI  - Laboratory information management system for membrane protein structure 
      initiative--from gene to crystal.
PG  - 639-52
LID - 10.1080/09687680802511766 [doi]
AB  - Membrane Protein Structure Initiative (MPSI) exploits laboratory competencies to 
      work collaboratively and distribute work among the different sites. This is 
      possible as protein structure determination requires a series of steps, starting 
      with target selection, through cloning, expression, purification, crystallization 
      and finally structure determination. Distributed sites create a unique set of 
      challenges for integrating and passing on information on the progress of targets. 
      This role is played by the Protein Information Management System (PIMS), which is 
      a laboratory information management system (LIMS), serving as a hub for MPSI, 
      allowing collaborative structural proteomics to be carried out in a distributed 
      fashion. It holds key information on the progress of cloning, expression, 
      purification and crystallization of proteins. PIMS is employed to track the 
      status of protein targets and to manage constructs, primers, experiments, 
      protocols, sample locations and their detailed histories: thus playing a key role 
      in MPSI data exchange. It also serves as the centre of a federation of 
      interoperable information resources such as local laboratory information systems 
      and international archival resources, like PDB or NCBI. During the challenging 
      task of PIMS integration, within the MPSI, we discovered a number of 
      prerequisites for successful PIMS integration. In this article we share our 
      experiences and provide invaluable insights into the process of LIMS adaptation. 
      This information should be of interest to partners who are thinking about using 
      LIMS as a data centre for their collaborative efforts.
FAU - Troshin, Petr V
AU  - Troshin PV
AD  - STFC Daresbury Science and Innovation Campus, Warrington, Cheshire, UK. 
      petr.troshin@stfc.ac.uk
FAU - Morris, Chris
AU  - Morris C
FAU - Prince, Stephen M
AU  - Prince SM
FAU - Papiz, Miroslav Z
AU  - Papiz MZ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mol Membr Biol
JT  - Molecular membrane biology
JID - 9430797
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Crystallography, X-Ray
MH  - Database Management Systems
MH  - Databases, Protein
MH  - Information Management
MH  - Information Storage and Retrieval/*methods
MH  - Internet
MH  - Membrane Proteins/*chemistry/genetics/isolation & purification/physiology
MH  - Models, Molecular
MH  - Proteomics/*methods
MH  - Software
MH  - Systems Integration
EDAT- 2008/11/11 09:00
MHDA- 2009/06/06 09:00
CRDT- 2008/11/11 09:00
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
AID - 905241067 [pii]
AID - 10.1080/09687680802511766 [doi]
PST - ppublish
SO  - Mol Membr Biol. 2008 Dec;25(8):639-52. doi: 10.1080/09687680802511766.