PMID- 18992723
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20221207
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1247
DP  - 2009 Jan 9
TI  - Expression and genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A 
      polymorphism in sporadic Alzheimer's disease in a Southern China population.
PG  - 178-81
LID - 10.1016/j.brainres.2008.10.019 [doi]
AB  - Alzheimer's disease (AD) is one of most common chronic neurodegenerative diseases 
      in the elderly. Tumor necrosis factor-alpha (TNF-alpha) was found elevated 
      markedly in the serum and the cerebral spinal fluid of AD patients. And the 
      elevation of TNF-alpha was thought to be associated with the occurrence of AD in 
      China. However, it is still unclear whether the TNF-alpha polymorphism is related 
      to the sporadic Alzheimer's disease (SAD) in China as well. Hence, in this study, 
      we try to investigate the relationship between TNF-alpha G-308A polymorphism and 
      its susceptibility to SAD in a Southern China population. The polymerase chain 
      reaction-sequence specific primers (PCR-SSP) was performed to detect the 
      frequencies of genotypes and alleles of TNF-alpha in 112 SAD patients and 121 
      controls. And the levels of TNF-alpha in serum were measured by radioimmunoassay. 
      The differences of polymorphic distribution and the levels of TNF-alpha in serum 
      between groups were then analyzed, and odds ratio was computed for association 
      analysis. The frequency of A-allele was significantly increased in patients with 
      SAD compared with that of the controls (chi(2)=4.256, P=0.039). A significantly 
      increased risk of SAD was observed in the carriers of A-allele (OR=2.635, 95% CI 
      1.027-6.763, P<0.01). In parallel, the serum level of TNF-alpha in SAD group was 
      much higher than that in control group (chi(2)=10.21, P=0.0042). And the 
      elevation of serum level of TNF-alpha was closely associated with the risk of SAD 
      (OR=3.542, 95% CI 2.304-8.854, P<0.05) as well. These results suggested that the 
      TNF-alpha gene G-308A polymorphism might be a risk factor for SAD in Southern 
      China. A-allele might play a role in the susceptibility of SAD.
FAU - Yang, Lianhong
AU  - Yang L
AD  - Department of Neurology, The Second Affiliated Hospital, Sun Yat-Sen University, 
      Guangzhou, 510120, PR China.
FAU - Lu, Ruiyan
AU  - Lu R
FAU - Jiang, Longyuan
AU  - Jiang L
FAU - Liu, Zhonglin
AU  - Liu Z
FAU - Peng, Ying
AU  - Peng Y
LA  - eng
PT  - Journal Article
DEP - 20081101
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Genetic Markers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/blood/ethnology/*genetics
MH  - Asian People/genetics
MH  - Brain Chemistry/*genetics
MH  - China/ethnology
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/blood/*genetics
MH  - Up-Regulation/genetics
EDAT- 2008/11/11 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/11/11 09:00
PHST- 2008/08/19 00:00 [received]
PHST- 2008/09/29 00:00 [revised]
PHST- 2008/10/04 00:00 [accepted]
PHST- 2008/11/11 09:00 [entrez]
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
AID - S0006-8993(08)02509-2 [pii]
AID - 10.1016/j.brainres.2008.10.019 [doi]
PST - ppublish
SO  - Brain Res. 2009 Jan 9;1247:178-81. doi: 10.1016/j.brainres.2008.10.019. Epub 2008 
      Nov 1.