PMID- 18992833
OWN - NLM
STAT- MEDLINE
DCOM- 20090129
LR  - 20170718
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 33
IP  - 1
DP  - 2009 Jan
TI  - Effect of hypoxic treatment on bone marrow cells that are able to migrate to the 
      injured liver.
PG  - 31-5
LID - 10.1016/j.cellbi.2008.10.002 [doi]
AB  - Restricted numbers and poor regenerative properties limit the use of adult stem 
      cells. We tested the effect of hypoxic treatment as a method by which to increase 
      cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations 
      of 0.1, 3, and 20% for 24h. After hypoxic treatment, BMCs of apoptotic fraction 
      were decreased. The expression of CXCR4 was noticeably increased in the 
      hypoxia-treated BMCs and their migration in response to SDF-1alpha was enhanced 
      compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher 
      degree of engraftment to the CCl(4)-injured liver than the normoxic cells. 
      Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells 
      as well as in enhancing cellular migration to SDF-1alpha, the chemokine which 
      binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl(4) damaged 
      liver.
FAU - Ju, Sun-Young
AU  - Ju SY
AD  - Department of Microbiology, Ewha Womans University College of Medicine, Ewha 
      Medical Research Center, Seoul, South Korea.
FAU - Cho, Kyung-Ah
AU  - Cho KA
FAU - Cho, Su Jin
AU  - Cho SJ
FAU - Jung, Yun-Jae
AU  - Jung YJ
FAU - Woo, So-Youn
AU  - Woo SY
FAU - Seoh, Ju-Young
AU  - Seoh JY
FAU - Han, Ho-Seong
AU  - Han HS
FAU - Ryu, Kyung-Ha
AU  - Ryu KH
LA  - eng
GR  - P30 DK067629/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081022
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Bone Marrow Cells/drug effects/*physiology
MH  - Bone Marrow Transplantation
MH  - Carbon Tetrachloride Poisoning/metabolism
MH  - Cell Hypoxia
MH  - Cell Movement/*physiology
MH  - Chemokine CXCL12/metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Liver/*drug effects/enzymology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Receptors, CXCR4/drug effects/metabolism
EDAT- 2008/11/11 09:00
MHDA- 2009/01/30 09:00
CRDT- 2008/11/11 09:00
PHST- 2008/03/26 00:00 [received]
PHST- 2008/05/24 00:00 [revised]
PHST- 2008/10/13 00:00 [accepted]
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/01/30 09:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
AID - S1065-6995(08)00593-3 [pii]
AID - 10.1016/j.cellbi.2008.10.002 [doi]
PST - ppublish
SO  - Cell Biol Int. 2009 Jan;33(1):31-5. doi: 10.1016/j.cellbi.2008.10.002. Epub 2008 
      Oct 22.