PMID- 18995849
OWN - NLM
STAT- MEDLINE
DCOM- 20090112
LR  - 20240109
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 109
IP  - 1
DP  - 2009 Jan
TI  - Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne 
      Mohawk young adults.
PG  - 86-92
LID - 10.1016/j.envres.2008.08.015 [doi]
AB  - Persistent organic pollutants, such as polychlorinated biphenyls (PCBs), 
      hexachlorobenzene (HCB), and p,p'-dichlorophenyldichloroethylene (DDE), have been 
      found to elicit a broad spectrum of biologic, metabolic, and immunologic 
      responses. The potential of these pollutants to impair immune responses and 
      trigger autoimmune disease is of growing concern, given their structural 
      similarity to thyroid hormones and their potential to modulate the mechanisms and 
      interfere with the binding of these hormones. We examine the relationship of 
      different groupings of PCBs, according to chlorination and structure, and of 
      p,p'-DDE and HCB to anti-thyroid peroxidase antibody, a useful tool in the 
      evaluation of thyroid dysfunction, among 115 young adults of the Akwesasne Mohawk 
      Nation. Overall, 18 participants (15.4%) had anti-thyroid peroxidase antibodies 
      (TPOAb) levels above the normal laboratory reference range (23% of females, 9% of 
      males). Among participants who were breast fed (n=47), those with an elevated 
      TPOAb level had significantly higher levels of all PCB groupings, with the 
      exception of levels of non-persistent PCBs which did not differ significantly. 
      Levels of p,p'-DDE were also significantly elevated, while HCB and mirex were not 
      higher among those with elevated TPOAb. Also, after stratifying by breast-feeding 
      status, participants who were breast fed showed significant, positive 
      relationships between TPOAb levels and all PCB groupings, except groups comprised 
      of non-persistent PCBs, and with p,p'-DDE, HCB, and mirex. No effects were 
      evident among non-breast-fed young adults. Further studies are necessary to 
      elucidate the site and mechanism of action of these persistent organic pollutants 
      (POPs) and to establish thresholds for these effects, especially among 
      populations with background levels of toxicant exposure.
FAU - Schell, Lawrence M
AU  - Schell LM
AD  - Department of Anthropology, University at Albany, A&S 237, 1400 Washington 
      Avenue, Albany, NY 12222, USA. l.schell@albany.edu
FAU - Gallo, Mia V
AU  - Gallo MV
FAU - Ravenscroft, Julia
AU  - Ravenscroft J
FAU - DeCaprio, Anthony P
AU  - DeCaprio AP
LA  - eng
GR  - R01 ES010904/ES/NIEHS NIH HHS/United States
GR  - R24 MD001120/MD/NIMHD NIH HHS/United States
GR  - R01 ES010904-05/ES/NIEHS NIH HHS/United States
GR  - 5RDMD001120/PHS HHS/United States
GR  - ES10904-06/ES/NIEHS NIH HHS/United States
GR  - R24 MD001120-03/MD/NIMHD NIH HHS/United States
GR  - ES04913-10/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081107
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Autoantibodies)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Thyroid Hormones)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Adolescent
MH  - Autoantibodies/*blood
MH  - *Environmental Exposure/adverse effects/analysis
MH  - *Environmental Pollutants/blood/toxicity
MH  - Female
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/blood/toxicity
MH  - *Indians, North American
MH  - Iodide Peroxidase/*immunology
MH  - Male
MH  - New York
MH  - Thyroid Hormones/blood
MH  - Young Adult
PMC - PMC2656648
MID - NIHMS90486
EDAT- 2008/11/11 09:00
MHDA- 2009/01/13 09:00
PMCR- 2010/01/01
CRDT- 2008/11/11 09:00
PHST- 2008/03/17 00:00 [received]
PHST- 2008/08/19 00:00 [revised]
PHST- 2008/08/25 00:00 [accepted]
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/01/13 09:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - S0013-9351(08)00189-8 [pii]
AID - 10.1016/j.envres.2008.08.015 [doi]
PST - ppublish
SO  - Environ Res. 2009 Jan;109(1):86-92. doi: 10.1016/j.envres.2008.08.015. Epub 2008 
      Nov 7.