PMID- 18996790
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20210204
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 14
IP  - 6
DP  - 2008 Sep
TI  - Synchronous thymoma and thymic carcinoid in a woman with multiple endocrine 
      neoplasia type 1: case report and review.
PG  - 713-6
AB  - OBJECTIVE: To report a rare case of multiple endocrine neoplasia type 1 (MEN 1) 
      in conjunction with concomitant thymoma and thymic carcinoid. METHODS: We 
      describe a never before reported case involving a 63-year-old female patient with 
      MEN 1 who had synchronous thymoma and thymic carcinoid tumors. A review of the 
      pertinent literature is also undertaken. RESULTS: Although prognosis is stage 
      dependent for patients with thymoma, patients with thymic carcinoids and MEN 1 
      have been reported to have an extremely poor prognosis, with many patients dying 
      of complications from thymic carcinoid rather than dying of other manifestations 
      of MEN 1. Our patient underwent successful surgical treatment and remains under 
      surveillance for all aspects of the MEN 1 syndrome. CONCLUSION: Thymic tumors are 
      rare, and thymic carcinoids, while very rare in occurrence overall, have a 
      definite association with MEN 1. Thus, it is important for practitioners to 
      screen for thymic tumors routinely in patients with MEN 1 and to treat such 
      tumors aggressively when found because they can be a major cause of mortality. 
      Many thymic carcinoids are far advanced before diagnosis, and optimal screening 
      for and treatment of thymic carcinoid are still being developed.
FAU - Miller, Barbra S
AU  - Miller BS
AD  - Division of Endocrine Surgery, Department of General Surgery, University of 
      Michigan, Ann Arbor, MI 48109-0331, USA.
FAU - Rusinko, Rachel Y
AU  - Rusinko RY
FAU - Fowler, Larry
AU  - Fowler L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
SB  - IM
MH  - Carcinoid Tumor/*diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/pathology
MH  - Thymoma/*diagnosis/pathology
MH  - Thymus Neoplasms/*diagnosis/pathology
RF  - 14
EDAT- 2008/11/11 09:00
MHDA- 2009/04/21 09:00
CRDT- 2008/11/11 09:00
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
AID - S1530-891X(20)41284-4 [pii]
AID - 10.4158/EP.14.6.713 [doi]
PST - ppublish
SO  - Endocr Pract. 2008 Sep;14(6):713-6. doi: 10.4158/EP.14.6.713.