PMID- 1899691
OWN - NLM
STAT- MEDLINE
DCOM- 19910315
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 56
IP  - 3
DP  - 1991 Mar
TI  - Analysis and quantitation of the beta-amyloid precursor protein in the 
      cerebrospinal fluid of Alzheimer's disease patients with a monoclonal 
      antibody-based immunoassay.
PG  - 1037-42
AB  - One of the major clinical findings in Alzheimer's disease (AD) is the formation 
      of deposits of beta-amyloid protein in amyloid plaques, derived from the 
      beta-amyloid precursor protein (beta-APP). To determine the possible use of 
      beta-APP as a diagnostic marker for AD in CSF, a monoclonal antibody-based 
      immunoassay specific for this protein was developed. The assay does not 
      differentiate between beta-APP695 and beta-APP751 forms but does preferentially 
      recognize beta-APP751 complexed with a protease. Of the two sets of CSF samples 
      tested, one set, obtained from living patients, gave a slightly lower level of 
      beta-APP in AD and Parkinson's disease patients relative to controls, whereas the 
      other set, composed of postmortem samples, showed no significant differences 
      between the AD and control groups.
FAU - Henriksson, T
AU  - Henriksson T
AD  - Athena Neurosciences, Inc., South San Francisco, California 94080.
FAU - Barbour, R M
AU  - Barbour RM
FAU - Braa, S
AU  - Braa S
FAU - Ward, P
AU  - Ward P
FAU - Fritz, L C
AU  - Fritz LC
FAU - Johnson-Wood, K
AU  - Johnson-Wood K
FAU - Chung, H D
AU  - Chung HD
FAU - Burke, W
AU  - Burke W
FAU - Reinikainen, K J
AU  - Reinikainen KJ
FAU - Riekkinen, P
AU  - Riekkinen P
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Protein Precursors)
SB  - IM
MH  - Alzheimer Disease/*cerebrospinal fluid
MH  - Amyloid beta-Peptides/*cerebrospinal fluid
MH  - Amyloid beta-Protein Precursor
MH  - *Antibodies, Monoclonal
MH  - Enzyme-Linked Immunosorbent Assay/*methods
MH  - Humans
MH  - Protein Precursors/*cerebrospinal fluid
MH  - Reference Values
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 10.1111/j.1471-4159.1991.tb02026.x [doi]
PST - ppublish
SO  - J Neurochem. 1991 Mar;56(3):1037-42. doi: 10.1111/j.1471-4159.1991.tb02026.x.