PMID- 18997171
OWN - NLM
STAT- MEDLINE
DCOM- 20090413
LR  - 20220408
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 113
IP  - 11
DP  - 2009 Mar 12
TI  - Acute graft-versus-host disease after unrelated donor umbilical cord blood 
      transplantation: analysis of risk factors.
PG  - 2410-5
LID - 10.1182/blood-2008-07-163238 [doi]
AB  - Acute graft-versus-host disease (GVHD) occurs less frequently after umbilical 
      cord blood transplantation (UCBT). More recent investigations include the use of 
      2 partially human leukocyte antigen (HLA)-matched UCB units, or double UCB graft, 
      to meet the minimum cell-dose requirement. The purpose of this analysis was to 
      assess the relative risk of acute GVHD in 265 consecutive patients receiving 
      transplants with UCB graft composed of 1 (n = 80) or 2 (n = 185) units. The 
      incidence of grade III-IV acute GVHD was similar between cohorts. However, the 
      incidence of grade II-IV acute GVHD was higher among double UCBT recipients (58 
      vs 39%, P < .01). Three risk factors for grade II-IV acute GVHD were identified 
      in multiple regression analysis: use of 2 UCB units, use of nonmyeloablative 
      conditioning, and absence of antithymocyte globulin in the conditioning regimen. 
      Transplantation-related mortality (TRM) at 1 year, however, was significantly 
      lower after double UCBT (24 vs 39%, P = .02) even if recipients had grade II-IV 
      acute GVHD (20 vs 39%, P = .05). These data suggest that, despite a higher 
      incidence of grade II acute GVHD in recipients of 2 partially HLA-matched UCB 
      units, there is no adverse effect on TRM. This study is registered at 
      (http://www.clinicaltrials.gov) under the identifiers NCT00305682 and 
      NCT00309842.
FAU - MacMillan, Margaret L
AU  - MacMillan ML
AD  - Blood and Marrow Transplant Program, University of Minnesota Medical School, 
      Minneapolis, MN 55455, USA. macmi002@umn.edu
FAU - Weisdorf, Daniel J
AU  - Weisdorf DJ
FAU - Brunstein, Claudio G
AU  - Brunstein CG
FAU - Cao, Qing
AU  - Cao Q
FAU - DeFor, Todd E
AU  - DeFor TE
FAU - Verneris, Michael R
AU  - Verneris MR
FAU - Blazar, Bruce R
AU  - Blazar BR
FAU - Wagner, John E
AU  - Wagner JE
LA  - eng
SI  - ClinicalTrials.gov/NCT00305682
SI  - ClinicalTrials.gov/NCT00309842
GR  - P01 CA065493/CA/NCI NIH HHS/United States
GR  - P01 CA65493/CA/NCI NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081107
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Donors
MH  - Blood Transfusion/mortality
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Fetal Blood/*transplantation
MH  - Graft vs Host Disease/*epidemiology/*etiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Transplantation Conditioning/methods
MH  - Transplantation, Homologous
MH  - Young Adult
PMC - PMC2656268
EDAT- 2008/11/11 09:00
MHDA- 2009/04/14 09:00
PMCR- 2010/03/12
CRDT- 2008/11/11 09:00
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/04/14 09:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
PHST- 2010/03/12 00:00 [pmc-release]
AID - S0006-4971(20)37566-2 [pii]
AID - 2008/163238 [pii]
AID - 10.1182/blood-2008-07-163238 [doi]
PST - ppublish
SO  - Blood. 2009 Mar 12;113(11):2410-5. doi: 10.1182/blood-2008-07-163238. Epub 2008 
      Nov 7.