PMID- 1899724
OWN - NLM
STAT- MEDLINE
DCOM- 19910320
LR  - 20190907
IS  - 0932-0113 (Print)
IS  - 0932-0113 (Linking)
VI  - 77
IP  - 1
DP  - 1991
TI  - Regulation of the human T-cell response to Schistosoma japonicum egg antigen by 
      concomitant cellular and humoral mechanisms in vitro.
PG  - 54-8
AB  - Serum-mediated regulation of T-cell responses specific for soluble egg antigen 
      (SEA) of Schistosoma japonicum was tested in human hosts. When we added 
      autologous serum to SEA-specific human T-cell lines (CD3+, 4+, 8-), we observed 
      suppression of T-cell proliferation, and this suppressive activity was detected 
      in the immunoglobulin-G2 (IgG2) subclass. Suppression was dose-dependent and 
      antigen-specific. T-cell proliferation induced by only one SEA fraction of 
      greater than 18 kDa was modulated in the presence of 100 micrograms/ml autologous 
      as well as allogeneic infected IgG2. This SEA fraction-driven proliferation was 
      also regulated by suppressor T-cells through distinct suppressive mechanisms. Our 
      results suggest that T-cell responses to a particular component(s) of SEA are 
      strictly regulated through both cellular and humoral mechanisms in human chronic 
      S. japonicum infection.
FAU - Ohta, N
AU  - Ohta N
AD  - Department of Parasitology, Okayama University Medical School, Japan.
FAU - Asahi, H
AU  - Asahi H
FAU - Hosaka, Y
AU  - Hosaka Y
FAU - Minai, M
AU  - Minai M
FAU - Ishii, A
AU  - Ishii A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Antibodies, Helminth/immunology
MH  - Antigens, Helminth/*immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Female
MH  - Humans
MH  - Immunodiffusion
MH  - Immunoglobulin G/immunology
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Ovum/immunology
MH  - Schistosoma japonicum/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1007/BF00934386 [doi]
PST - ppublish
SO  - Parasitol Res. 1991;77(1):54-8. doi: 10.1007/BF00934386.