PMID- 18997284
OWN - NLM
STAT- MEDLINE
DCOM- 20090112
LR  - 20191027
IS  - 0951-6433 (Print)
IS  - 0951-6433 (Linking)
VI  - 31
IP  - 3-4
DP  - 2007
TI  - Influence of Coenzyme Q_10 on release of pro-inflammatory chemokines in the 
      human monocytic cell line THP-1.
PG  - 211-7
AB  - Coenzyme Q_10 (CoQ_10) is an obligatory element in the mitochondrial electron 
      transport system and functions as a potent antioxidant of lipid membranes. 
      In-vivo and in-vitro studies indicate an involvement of CoQ_10 in inflammatory 
      pathways. Here we studied in the human monocytic cell-line THP-1 the influence of 
      CoQ_10 on LPS-induced secretion of the pro-inflammatory chemokines Macrophage 
      inflammatory protein-1 alpha (MIP-1alpha), Regulated upon activation, normal T 
      cell expressed and secreted (RANTES) and Monocyte chemoattractant protein-1 
      (MCP-1). In comparison to unstimulated cells, LPS leads to 22-, 3- and 4.5-fold 
      higher levels of MIP-1alpha, RANTES and MCP-1 in the cell culture medium, 
      respectively. Pre-incubation of cells with 10 microM CoQ_10 resulted in a 
      significant decrease of LPS-induced MIP-1alpha and RANTES secretion to 55.04% (p 
      = 0.02) and 76.84% (p = 0.04), respectively. In conclusion, CoQ_10 reduces the 
      LPS-induced secretion levels of the pro-inflammatory chemokines MIP-1alpha and 
      RANTES in the human monocytic cell line THP-1. These data suggest that CoQ_10 
      possesses anti-inflammatory properties.
FAU - Schmelzer, Constance
AU  - Schmelzer C
AD  - Institute of Human Nutrition and Food Science, Molecular Nutrition, 
      Christian-Albrechts-University of Kiel, Germany.
FAU - Lorenz, Gerti
AU  - Lorenz G
FAU - Rimbach, Gerald
AU  - Rimbach G
FAU - Doring, Frank
AU  - Doring F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Lipopolysaccharides)
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Chemokine CCL2/metabolism
MH  - Chemokines/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Lipopolysaccharides/pharmacology
MH  - Monocytes/cytology/*drug effects/metabolism
MH  - Ubiquinone/*analogs & derivatives/pharmacology
EDAT- 2008/11/11 09:00
MHDA- 2009/01/13 09:00
CRDT- 2008/11/11 09:00
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2009/01/13 09:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
AID - 10.1002/biof.5520310308 [doi]
PST - ppublish
SO  - Biofactors. 2007;31(3-4):211-7. doi: 10.1002/biof.5520310308.