PMID- 19000131
OWN - NLM
STAT- MEDLINE
DCOM- 20090824
LR  - 20081204
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 6
DP  - 2008 Dec
TI  - Major histocompatibility complex class I chain-related gene A polymorphism and 
      linkage disequilibrium with HLA-B alleles in Euro-Brazilians.
PG  - 532-8
LID - 10.1111/j.1399-0039.2008.01142.x [doi]
AB  - Major histocompatibility complex class I chain-related gene A (MICA) was 
      identified within the human leukocyte antigen (HLA) class I region and was 
      located 46 kb centromeric from HLA-B locus. It functions as a ligand for human 
      gammadelta T, CD8 T and natural killer (NK) cells by binding the NKG2D receptor. 
      The aims of the present study were to determine the distribution of MICA alleles 
      and MICA-HLA-B haplotypes in a sample of Euro-Brazilians. Through the combination 
      of three typing methods, polymerase chain reaction (PCR)-sequence-specific 
      oligonucleotide probe, PCR-sequence-specific primer and PCR-restriction fragment 
      length polymorphism, 19 alleles were detected besides a MICA gene deletion in a 
      sample composed by 204 unrelated Euro-Brazilians. The most commonly observed 
      alleles were: MICA*00801 (25.3%), MICA*00201 (17.7%) and MICA*00901 (13.7%). The 
      GCT repeat polymorphism variant A6 was the most commonly found. The most frequent 
      haplotype found in this study was MICA*00901-B*51 (8.1%), followed by haplotypes 
      MICA*00201-B*35 (6.1%) and MICA*00801-B*07 (6.1%). MICA*00801 truncated product, 
      and its low affinity for NKG2D receptor may work as an inhibitor in its putative 
      soluble form. It may also be that selective forces may favor MICA*00801 
      heterozygosity with NKG2D high affinity MICA alleles enabling activation and 
      inhibition of cytotoxic activity of cells expressing the NKG2D receptor. The 
      possibility of selective neutrality or of balancing selection still provides no 
      explanation for MICA gene polymorphisms. Is it maintained by genetic drift or by 
      the influence of migratory waves? Are there favored alleles while others present 
      the same adaptive value?
FAU - Ribas, F
AU  - Ribas F
AD  - Laboratory of Immunogenetics and Histocompatibility, Department of Genetics, 
      Universidade Federal do Parana, Curitiba, Brazil.
FAU - Oliveira, L A
AU  - Oliveira LA
FAU - Petzl-Erler, M L
AU  - Petzl-Erler ML
FAU - Bicalho, M G
AU  - Bicalho MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081017
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily K)
SB  - IM
MH  - Alleles
MH  - Brazil
MH  - Europe/ethnology
MH  - Gene Frequency/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - Linkage Disequilibrium/*genetics/immunology
MH  - NK Cell Lectin-Like Receptor Subfamily K/*genetics/immunology
MH  - Polymorphism, Genetic
EDAT- 2008/11/13 09:00
MHDA- 2009/08/25 09:00
CRDT- 2008/11/13 09:00
PHST- 2008/11/13 09:00 [pubmed]
PHST- 2009/08/25 09:00 [medline]
PHST- 2008/11/13 09:00 [entrez]
AID - TAN1142 [pii]
AID - 10.1111/j.1399-0039.2008.01142.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Dec;72(6):532-8. doi: 10.1111/j.1399-0039.2008.01142.x. 
      Epub 2008 Oct 17.