PMID- 19000139
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 1
DP  - 2009 Jan
TI  - Effect of polymorphism in insulin locus and HLA on type 1 diabetes in four ethnic 
      groups in Israel.
PG  - 33-8
LID - 10.1111/j.1399-0039.2008.01153.x [doi]
AB  - This study examined a possible association of the insulin (INS) gene with type 1 
      diabetes (T1D) in patients and controls from four ethnic groups in Israel. We 
      analyzed the distribution of -23HphI single nucleotide polymorphism (SNP) T/A 
      alleles that correspond to INS variable number of tandem repeat short class I 
      alleles (26-63 repeats) and class III alleles (141-209 repeats), respectively. 
      The -23HphI T/T genotype was found to be positively associated with T1D in three 
      Jewish groups (Yemenites: 93.9% patients vs 68.8% controls, P = 0.0002; 
      Ashkenazi: 80.6% vs 50.8%, P < 10(-4); Ethiopians: 75% vs 40.5%, P = 0.002). The 
      Yemenite healthy controls have the highest frequency of T allele from all Jewish 
      groups studied (83.5% vs 68.8% in Ashkenazi and 64.3% in Ethiopians). The high 
      frequency of a susceptibility allele in the Yemenites is in line with the high 
      incidence of T1D in this population. No association was observed between T1D and 
      the INS gene in Israeli Arabs studied (70.6% vs 66.7%). Variable incidence of T1D 
      among different ethnicities in Israel is largely attributed to heterogeneous 
      genetics. Human leukocyte antigen (HLA) results of our previous studies 
      describing the susceptibility and protective haplotypes were used for combined 
      analysis to determine possible interaction between the HLA and INS loci. Only in 
      the Ashkenazi group such interaction was presented with statistical significance.
FAU - Benedek, G
AU  - Benedek G
AD  - The Lautenberg Center for General and Tumor Immunology, Hebrew 
      University-Hadassah Medical School, Jerusalem, Israel.
FAU - Brautbar, C
AU  - Brautbar C
FAU - Vardi, P
AU  - Vardi P
FAU - Sharon, N
AU  - Sharon N
FAU - Weintrob, N
AU  - Weintrob N
FAU - Zung, A
AU  - Zung A
FAU - Israel, S
AU  - Israel S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081024
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Diabetes Mellitus, Type 1/*ethnology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Insulin/*genetics
MH  - Israel
MH  - Minisatellite Repeats
MH  - Polymorphism, Single Nucleotide
MH  - Young Adult
EDAT- 2008/11/13 09:00
MHDA- 2009/03/07 09:00
CRDT- 2008/11/13 09:00
PHST- 2008/11/13 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
PHST- 2008/11/13 09:00 [entrez]
AID - TAN1153 [pii]
AID - 10.1111/j.1399-0039.2008.01153.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jan;73(1):33-8. doi: 10.1111/j.1399-0039.2008.01153.x. Epub 
      2008 Oct 24.