PMID- 19000140
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 1
DP  - 2009 Jan
TI  - HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish Eastern 
      European Americans from the general European American population.
PG  - 17-32
LID - 10.1111/j.1399-0039.2008.01151.x [doi]
AB  - Sequence-based typing was used to identify human leukocyte antigen (HLA)-A, -B, 
      -C, and -DRB1 alleles from 558 consecutively recruited US volunteers with Eastern 
      European ancestry for an unrelated hematopoietic stem cell registry. Four of 31 
      HLA-A alleles, 29 HLA-C alleles, 59 HLA-B alleles, and 42 HLA-DRB1 alleles 
      identified (A*0325, B*440204, Cw*0332, and *0732N) are novel. The HLA-A*02010101g 
      allele was observed at a frequency of 0.28. Two-, three-, and four-locus 
      haplotypes were estimated using the expectation-maximization algorithm. The 
      highest frequency extended haplotypes (A*010101g-Cw*070101g-B*0801g-DRB1*0301 and 
      A*03010101g-Cw*0702-B*0702-DRB1*1501) were observed at frequencies of 0.04 and 
      0.03, respectively. Linkage disequilibrium values (Dij') of the constituent 
      two-locus haplotypes were highly significant for both extended haplotypes (P 
      values were less than 8 x 10(-10)) but were consistently higher for the more 
      frequent haplotype. Balancing selection was inferred to be acting on all the four 
      loci, with the strongest evidence of balancing selection observed for the HLA-C 
      locus. Comparisons of the A-C-B haplotypes and DRB1 frequencies in this 
      population with those for African, European, and western Asian populations showed 
      high degrees of identity with Czech, Polish, and Slovenian populations and 
      significant differences from the general European American population.
FAU - Mack, S J
AU  - Mack SJ
AD  - Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA. 
      sjmack@chori.org
FAU - Tu, B
AU  - Tu B
FAU - Lazaro, A
AU  - Lazaro A
FAU - Yang, R
AU  - Yang R
FAU - Lancaster, A K
AU  - Lancaster AK
FAU - Cao, K
AU  - Cao K
FAU - Ng, J
AU  - Ng J
FAU - Hurley, C K
AU  - Hurley CK
LA  - eng
GR  - R01 GM035326-16/GM/NIGMS NIH HHS/United States
GR  - GM35326/GM/NIGMS NIH HHS/United States
GR  - R01 GM035326/GM/NIGMS NIH HHS/United States
GR  - P30 CA051008/CA/NCI NIH HHS/United States
GR  - U01 AI067068-04/AI/NIAID NIH HHS/United States
GR  - U01 AI067068-05/AI/NIAID NIH HHS/United States
GR  - U01 AI067068/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20081024
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Alleles
MH  - Europe/ethnology
MH  - Europe, Eastern/ethnology
MH  - Gene Frequency/*genetics
MH  - Genetic Variation
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - White People/*genetics
PMC - PMC3495166
MID - NIHMS411144
EDAT- 2008/11/13 09:00
MHDA- 2009/03/07 09:00
PMCR- 2012/11/11
CRDT- 2008/11/13 09:00
PHST- 2008/11/13 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
PHST- 2008/11/13 09:00 [entrez]
PHST- 2012/11/11 00:00 [pmc-release]
AID - TAN1151 [pii]
AID - 10.1111/j.1399-0039.2008.01151.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jan;73(1):17-32. doi: 10.1111/j.1399-0039.2008.01151.x. 
      Epub 2008 Oct 24.