PMID- 19001753
OWN - NLM
STAT- MEDLINE
DCOM- 20090316
LR  - 20191111
IS  - 1882-0476 (Electronic)
IS  - 0916-4804 (Linking)
VI  - 49
IP  - 4
DP  - 2008
TI  - [Our efforts to curb systemic fungal infections].
PG  - 275-80
AB  - The number of systemic fungal infection (SFI) cases is going due to the increase 
      in immunocompromised hosts associated with advanced chemotherapy and high-tech 
      medical devices. Aspergillus, Candida and Cryptococcus are major etiologies of 
      SFIs and a remarkable increase of aspergillosis has been noted. The problems of 
      SFIs in general are lower diagnostic rate and worse prognosis compared to 
      infections by other pathogens. Clinical concerns of SFIs are the low diagnostic 
      rate of aspergillosis, lack of evidence for treatment of chronic aspergillosis, 
      poor outcome of cryptococcal encephalomeningitis of immunocompromised hosts, and 
      increasing low azole-susceptible Candida. Our final goal is to overcome these 
      problems and to develop a newer rapid diagnostic tool for aspergillosis, 
      establish clinical trials for chronic aspergillosis, discover new pathogenic 
      factors of Cryptococcus and evaluate alternative treatment for low azole 
      susceptible Candida infections. We believe research advances in these areas will 
      be useful in the diagnosing and treatment of SFIs in the future.
FAU - Izumikawa, Koichi
AU  - Izumikawa K
AD  - Second Department of Internal Medicine, Nagasaki University School of Medicine, 
      Nagasaki, Japan.
FAU - Kohno, Shigeru
AU  - Kohno S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Ishinkin Gakkai Zasshi
JT  - Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology
JID - 9425640
SB  - IM
MH  - Humans
MH  - Mycoses/*diagnosis/*drug therapy
RF  - 12
EDAT- 2008/11/13 09:00
MHDA- 2009/03/17 09:00
CRDT- 2008/11/13 09:00
PHST- 2008/11/13 09:00 [pubmed]
PHST- 2009/03/17 09:00 [medline]
PHST- 2008/11/13 09:00 [entrez]
AID - JST.JSTAGE/jjmm/49.275 [pii]
AID - 10.3314/jjmm.49.275 [doi]
PST - ppublish
SO  - Nihon Ishinkin Gakkai Zasshi. 2008;49(4):275-80. doi: 10.3314/jjmm.49.275.